Copper-promoted dehydrogenative cross-coupling reaction of dialkyl phosphites with sulfoximines?

Organic Chemistry Frontiers Pub Date: 2019-05-06 DOI: 10.1039/C9QO00469F

Abstract

An efficient method for the dehydrogenative cross-coupling of dialkyl phosphites with sulfoximines is demonstrated in the presence of copper(II) acetate and triethylamine. A library of sulfoximines including aryl, heteroaryl and alkyl sulfoximines underwent coupling reaction smoothly and gave the desired sulfoximine derived phosphoramidates in good to excellent yields.

Graphical abstract: Copper-promoted dehydrogenative cross-coupling reaction of dialkyl phosphites with sulfoximines
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