Copper-catalyzed three-component reaction of N-heteroaryl aldehydes, nitriles, and water?
Organic & Biomolecular Chemistry Pub Date: 2019-04-24 DOI: 10.1039/C9OB00599D
Abstract
An efficient and straightforward method for the synthesis of N-heteroaroyl imides has been successfully developed involving a copper-catalyzed radical-triggered three-component reaction of N-heteroaryl aldehydes, nitriles, and water. Mechanistic studies indicate that the reaction may undergo a radical-triggered Ritter-type reaction in which water serves as the oxygen source for the formation of the C–O bond. The reaction has advantages such as a broad substrate scope for the N-heteroaryl aldehydes, atom economy, and simple operation.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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