Copper-catalyzed tandem trifluoromethylation/cyclization of internal alkynes?
Organic Chemistry Frontiers Pub Date: 2014-11-04 DOI: 10.1039/C4QO00240G
Abstract
Copper-catalyzed tandem trifluoromethylation/cyclization of internal alkynes with Umemoto's reagent leads to 3-trifluoromethyl-1,2-dihydronaphthalene derivatives in moderate to good yields. The utility of this copper-catalyzed tandem reaction was demonstrated by oxidizing and reducing the trifluoromethylated product to give naphthalene and tetrahydronaphthalene, respectively, and the development of a short route to a trifluoromethylated analogue of Nafoxidine.
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Journal Name：Organic Chemistry Frontiers
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