Copper-catalyzed oxidative cyclization of glycine derivatives toward 2-substituted benzoxazoles?

Organic & Biomolecular Chemistry Pub Date: 2021-01-30 DOI: 10.1039/D0OB02490B

Abstract

A novel and straightforward intramolecular cyclization of glycine derivatives to 2-substituted benzoxazoles through copper-catalyzed oxidative C–H/O–H cross-coupling was described. A variety of glycine derivatives involving short peptides underwent cross-dehydrogenative-coupling readily to afford diverse 2-substituted benzoxazoles. The synthetic method has the advantages of simple operation, broad substrate scope and mild reaction conditions, thus providing an alternative effective approach for benzoxazole construction.

Graphical abstract: Copper-catalyzed oxidative cyclization of glycine derivatives toward 2-substituted benzoxazoles
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