Copper-catalyzed ortho-halogenation of arenes and heteroarenes directed by a removable auxiliary?

Chemical Communications Pub Date: 2015-02-17 DOI: 10.1039/C5CC00531K

Abstract

Copper-catalyzed ortho-halogenation of C(sp2)–H bonds directed by a PIP directing group with NXS (X = Cl, Br, I) has been developed. The reaction is scalable and tolerates a broad range of functional groups and heteroarenes, providing an efficient access to halogenated arenes and heteroarenes.

Graphical abstract: Copper-catalyzed ortho-halogenation of arenes and heteroarenes directed by a removable auxiliary
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