Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl2 as a stoichiometric formylating reagent?
Chemical Science Pub Date: 2018-02-14 DOI: 10.1039/C8SC00210J
Abstract
The first example of copper-catalyzed direct formylation of alkenyl C–H bonds for the facile synthesis of α,β-unsaturated aldehydes has been developed. This transformation has demonstrated high reactivity, mild reaction conditions and a broad substrate scope. BrCHCl2 is expected to be developed as an efficient stoichiometric C1 building block in organic synthesis.
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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