Copper-catalyzed formation of N,N-dimethyl benzamide from nitrile and DMF under an O2 atmosphere?

Organic & Biomolecular Chemistry Pub Date: 2013-10-16 DOI: 10.1039/C3OB41855C

Abstract

Amidation of nitrile with N,N-dimethylformamide (DMF) was catalyzed by Cu2O with 1,10-phenanthroline as a ligand under an oxygen atmosphere. A variety of N,N-dimethyl benzamides were obtained in yields up to 84%.

Graphical abstract: Copper-catalyzed formation of N,N-dimethyl benzamide from nitrile and DMF under an O2 atmosphere
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