Copper(ii)-mediated oxidative cyclization of enamides to oxazoles?

Organic & Biomolecular Chemistry Pub Date: 2012-03-23 DOI: 10.1039/C2OB25310K

Abstract

The copper(II)-mediated oxidative cyclization of enamides to oxazoles is reported. A range of 2,5-disubstituted oxazoles were prepared in moderate to good yields in two steps from simple amide and alkyne precursors.

Graphical abstract: Copper(ii)-mediated oxidative cyclization of enamides to oxazoles
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