Conformational promiscuity in triazolamers derived from quaternary amino acids mimics peptide behaviour?

Organic & Biomolecular Chemistry Pub Date: 2015-10-02 DOI: 10.1039/C5OB01461A

Abstract

1,4-Substituted triazole oligomers made from quaternary amino acid derivatives present a conformational behaviour with similarities to that of natural peptides. Twisted strand and zig-zag type conformations have both been obtained in the crystal state. In a solution signs of weakly ordered structures have been detected depending on the substituents and the solvents used.

Graphical abstract: Conformational promiscuity in triazolamers derived from quaternary amino acids mimics peptide behaviour
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