Bromine–lithium exchange under non-cryogenic conditions: TMSCH2Li–LiDMAE promoted C-2 lithiation of 2,3-dibromopyridine?

Chemical Communications Pub Date: 2008-08-20 DOI: 10.1039/B810453K

Abstract

The first C-2 selective bromine–lithium exchange in 2,3-dibromopyridine was performed at 0 °C in toluene using the TMSCH2Li–LiDMAE reagent.

Graphical abstract: Bromine–lithium exchange under non-cryogenic conditions: TMSCH2Li–LiDMAE promoted C-2 lithiation of 2,3-dibromopyridine
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