Chemical and biological evaluation of unusual sugars, α-aculosides, as novel Michael acceptors?
Organic & Biomolecular Chemistry Pub Date: 2014-09-18 DOI: 10.1039/C4OB01877J
Abstract
The unusual sugars, α-aculosides, which appear in certain antibiotics and have an α,β-unsaturated ketone structure, were found to be novel and selective Michael acceptors for the thiol function of cysteine residues. A coumarin derivative possessing α-aculoside as a Michael acceptor effectively and irreversibly operated as a fluorescent probe in cells. Furthermore, α-aculosides exhibited cytotoxic activity against several cancer cell lines.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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