A facile one-pot sonochemical synthesis of surface-coated mannosyl protein microspheres for detection and killing of bacteria?

Chemical Communications Pub Date: 2011-08-22 DOI: 10.1039/C1CC13518J

Abstract

We report a remarkably facile one-pot sonochemical approach to prepare protein microspheres whose shells are covalently decorated with a mannosyl derivative to target Escherichia coli (E. coli), while their cores are encapsulated with tetracycline. Conjugated microspheres induced the agglutination of E. coli and increased the anti-bacterial activity of the encapsulated tetracycline by five fold.

Graphical abstract: A facile one-pot sonochemical synthesis of surface-coated mannosyl protein microspheres for detection and killing of bacteria
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