Combined C–H functionalization/O–H insertion reaction to form tertiary β-alkoxy substituted β-aminophosphonates catalyzed by [Cu(MeCN)4]PF6??

Organic & Biomolecular Chemistry Pub Date: 2013-07-02 DOI: 10.1039/C3OB40941D

Abstract

The copper-catalyzed C–H functionalization/O–H insertion reaction of α-diazophosphonates with alcohols has been developed with iodine as an additive. In order to understand this reaction, we present here a possible mechanism for the combined reaction. This process provides straightforward access to tertiary β-alkoxy substituted β-aminophosphonate derivatives with moderate to good yields.

Graphical abstract: Combined C–H functionalization/O–H insertion reaction to form tertiary β-alkoxy substituted β-aminophosphonates catalyzed by [Cu(MeCN)4]PF6
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