A facile approach to 2-alkoxyindolin-3-one and its application to the synthesis of N-benzyl matemone?

RSC Advances Pub Date: 2019-06-03 DOI: 10.1039/C9RA02204J

Abstract

2-Alkoxycarbonylindolin-3-one is synthesized from a methoxyglycine derivative via a 1,2-aza-Brook rearrangement followed by cyclization with bis(trimethylsilyl)aluminum chloride. A short-step synthesis of N-benzyl matemone is successfully carried out using the present indolin-3-one synthesis.

Graphical abstract: A facile approach to 2-alkoxyindolin-3-one and its application to the synthesis of N-benzyl matemone
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