A facile approach for the synthesis of C13–C24 fragments of maltepolides A, C and D?
Organic & Biomolecular Chemistry Pub Date: 2016-09-06 DOI: 10.1039/C6OB01447J
Abstract
A linear, chiron approach for the synthesis of C13–C24 fragments of cytostatic maltepolides A, C and D consisting of a tetrahydrofuran subunit and a chiral alkenyl/alkyl substituent is achieved from (+)-diethyl L-tartrate. The other chiral stereocenters were generated by employing key reactions such as Crimmins aldol, alkynylation and CeCl3·7H2O mediated Luche reduction reactions.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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