Combinatorial synthesis of spiro[indoline-3,2′-pyrrole] derivatives via a three-component reaction under catalyst-free conditions?
RSC Advances Pub Date: 2016-01-19 DOI: 10.1039/C5RA23860A
Abstract
Reported here is a convenient catalyst-free method for preparing a series of spiro[indoline-3,2′-pyrroles] from a three-component reaction of isatins, α-amino acid and phenylpropiolic acid esters in refluxing isopropanol with high regioselectivity and yields. A plausible mechanism for this process was proposed. In addition, this protocol permitted the facile construction of spiro[indoline-3,2′-pyrroles] through an expanded scope of substrates.
![Graphical abstract: Combinatorial synthesis of spiro[indoline-3,2′-pyrrole] derivatives via a three-component reaction under catalyst-free conditions](http://scimg.chem960.com/usr/1/C5RA23860A.jpg)
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Journal Name：RSC Advances
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