Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand?
Dalton Transactions Pub Date: 2020-03-24 DOI: 10.1039/D0DT00507J
Abstract
Pt-ATRA, a carboplatin analogue containing an all-trans retinoic acid (ATRA) derivative ligand, was synthesized via a click reaction. Upon cellular internalization, Pt-ATRA exhibits a dual function, releasing an active Pt(II) moiety to induce cell apoptosis and ATRA to inhibit tumor metastasis.
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Journal Name：Dalton Transactions
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CAS no.: 89640-58-4
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