Cobalt-catalyzed coupling reactions of 2-halobenzamides with alkynes: investigation of ligand-controlled dual pathways?
Organic Chemistry Frontiers Pub Date: 2021-09-24 DOI: 10.1039/D1QO01402A
Abstract
The Co-catalyzed reactions of 2-halobenzamides and alkynes to form isoquinolones or 2-vinyl benzamides are described here. The formation of the two selective products can be fully controlled by adopted ligands. A study of the mechanism demonstrated that these two reactions proceed through different pathways. The radical process and the two-electron transfer activation of the C–X bond are respectively proposed for these two reactions.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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