Cobalamin-dependent radical S-adenosyl-l-methionine enzymes in natural product biosynthesis
Natural Product Reports Pub Date: 2018-08-06 DOI: 10.1039/C7NP00059F
Abstract
Covering: 2011 to 2018
This highlight summarizes the investigation of cobalamin (Cbl)- and radical S-adenosyl-L-methionine (SAM)-dependent enzymes found in natural product biosynthesis to date and suggests some possibilities for the future. Though some mechanistic aspects are apparently shared, the overall diversity of this family's functions and abilities is significant and may be tailored to the specific substrate and/or reaction being catalyzed. A little over a year ago, the first crystal structure of a Cbl- and radical SAM-dependent enzyme was solved, providing the first insight into what may be the shared scaffolding of these enzymes.
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Journal Name：Natural Product Reports
research_products
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CAS no.: 89640-58-4
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