Thiazoles
Thiazoles are a class of heterocyclic organic compounds containing a five-membered ring with sulfur (S) and nitrogen (N) atoms, specifically the structure R-S=NR', where R and R' can be various alkyl or aryl groups. These compounds exhibit diverse chemical properties depending on their substituents, making them versatile for various applications.
Thiazoles are widely used in pharmaceuticals due to their structural diversity and biological activity. For instance, they have been identified as potential leads for the treatment of diseases such as HIV, tuberculosis, and cancer. Additionally, thiazoles find application in agrochemicals as herbicides and fungicides due to their ability to inhibit specific enzymes or disrupt cell processes.
Structurally, thiazoles can be synthesized through various methods including condensation reactions between isothiocyanates and amines, as well as other nucleophilic substitution reactions. Their synthesis can also involve more complex methodologies such as microwave-assisted techniques for enhanced efficiency.
The unique properties of thiazoles make them indispensable in both academic research and industrial applications across multiple sectors.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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Thiazole-5-carbonitrile | 25742-12-5 | C4H2N2S |
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2-Methyl-4-isothiazolin-3-one hydrochloride | 26172-54-3 | C4H6ClNOS |
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Aminothiazole | 96-50-4 | C3H4N2S |
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1-(1,3-thiazol-5-yl)propan-2-one | 106613-45-0 | C6H7NOS |
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2(3H)-Thiazolone, 4-(acetyloxy)- | 62581-01-5 | C5H5NO3S |
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2,4-Dihydroxythiazole | 62326-99-2 | C3H3NO2S |
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Calcium,dichloro(2-methyl-3(2H)-isothiazolone-O)- (9CI) | 57373-20-3 | C4H5CaCl2NOS |
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2(3H)-Thiazolethione,3,4-dimethyl- | 5316-79-0 | C5H7NS2 |
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2-(2-methyloxiran-2-yl)-1,3-thiazole | 216503-31-0 | C6H7NOS |
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4H,6H,7H-pyrano4,3-d1,3thiazole | 259810-14-5 | C6H7NOS |
Related Literature
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Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
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Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592
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Kui Wu,Zhihua Yang,Shilie Pan Dalton Trans., 2015,44, 19856-19864
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Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
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Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
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