Quebrachamine alkaloids are a class of natural products isolated from various species of South American quebracho trees, particularly *Schinopsis brasiliensis*. These alkaloids exhibit a diverse range of biological activities, including antitumor, antibacterial, and anti-inflammatory properties. Structurally, they feature complex molecular frameworks with nitrogen-containing heterocycles, contributing to their unique pharmacological effects. Quebrachamine derivatives are often studied for potential therapeutic applications due to their ability to modulate various cellular processes. Their structure-activity relationships have been extensively explored in both academic research and industrial development, aiming to optimize their efficacy and reduce side effects. In pharmaceutical research, these alkaloids serve as valuable tools for understanding the mechanisms of action associated with their biological activities. These natural products represent promising leads in drug discovery, particularly in the development of new therapeutic agents targeting cancer and inflammatory diseases.