Piperidines
Piperidines are a class of heterocyclic compounds characterized by a six-membered ring containing one nitrogen atom. These molecules exhibit a wide range of biological activities and are of significant interest in pharmaceutical and chemical research due to their potential as drug leads and functional materials. Piperidines can be found in various natural products, such as alkaloids from plants, and are also synthesized for use in organic synthesis, polymer science, and material engineering.
Structurally, piperidine features a nitrogen atom adjacent to three carbon atoms within the ring, creating a cyclic amine. This basic structure allows for diverse functionalization, making piperidines versatile building blocks for synthesizing complex molecules. They are commonly used as precursors in the preparation of other heterocycles and pharmaceuticals due to their unique reactivity.
In drug development, piperidines often act as scaffolds that can be easily modified to enhance their potency, selectivity, or pharmacokinetic properties. For instance, they have been utilized in the design of antihistamines, antipsychotics, and analgesics. Additionally, certain piperidine derivatives possess antimicrobial, antioxidant, and anti-inflammatory activities, making them valuable candidates for further biological evaluation.
Overall, piperidines represent a chemically rich family with broad applications across multiple scientific fields, driven by their structural diversity and functional reactivity.
- Piperidinecarboxylic acids and derivatives
- Phenylpiperidines
- N-acylpiperidines
- Benzylpiperidines
- Aminopiperidines
- Piperidinones
- Piperidinesulfonamides
- Piperidines
- Piperidinecarboxylic acids
- Nitrosopiperidines
- Piperidinediones
- Fentanyls
- 3-benzylpiperidines
- N-benzylpiperidines
- Piperidinecarboxamides
- 2-benzylpiperidines
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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3-(2-Ethylpiperidin-1-yl)propan-1-amine | 13901-38-7 | C10H22N2 |
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4-(Chloromethyl)-1-methylpiperidine hydrochloride | 1182284-45-2 | C7H15Cl2N |
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Lucerastat | 141206-42-0 | C10H21NO4 |
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1-(2-Aminoethyl)piperidin-4-ol | 129999-60-6 | C7H16N2O |
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4-(1H-1,2,4-triazol-1-yl)piperidine | 158655-26-6 | C7H12N4 |
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1-(propan-2-yl)piperidine-4-thiol | 156757-18-5 | C8H17NS |
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1-Azabicyclo[2.2.1]heptan-3-ylmethanamine | 159996-27-7 | C7H14N2 |
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N-(7-Oxadecyl)deoxynojirimycin | 160632-05-3 | C15H31NO5 |
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4-Piperidinecarbonylchloride | 190142-48-4 | C6H10ClNO |
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1-(azetidin-3-yl)-4-fluoropiperidine | 194427-25-3 | C8H15FN2 |
Related Literature
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Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
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Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
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Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
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Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
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