Phenylpiperazines
Phenylpiperazines are a class of organic compounds characterized by the presence of an amino-piperazine group attached to a phenyl ring. These molecules are widely studied for their diverse applications in pharmaceuticals, agrochemicals, and materials science due to their unique structural features and biological properties.
Structurally, phenylpiperazines consist of a piperazine moiety with one or more nitrogen atoms substituted by a phenyl group. This substitution pattern can vary, leading to different isomers and derivatives. The chemical stability and reactivity of these compounds are influenced by the specific substituents on both the phenyl ring and the piperazine ring.
In pharmaceutical research, phenylpiperazines have shown potential as agonists or antagonists for various receptor systems, including muscarinic receptors and histamine H3 receptors. They also exhibit promising activities in managing pain, inflammation, and other neurological disorders. In agrochemical applications, these compounds can serve as herbicides or fungicides due to their ability to interact with plant enzymes or cellular targets.
Due to their structural complexity and versatile functionalities, phenylpiperazines continue to be an active area of investigation for developing novel therapeutic agents and agricultural chemicals.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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5-Methyl-2-((3-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4(3H)-one | 1245642-85-6 | C16H21N5O |
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3-(3,4-Dichlorophenyl)piperazin-2-one | 334477-10-0 | C10H10Cl2N2O |
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N-[2-(furan-2-yl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]-1,3-benzothiazole-2-carboxamide | 1210275-91-4 | C25H26N4O3S |
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3-Fluoro-4-(4-methylpiperazin-1-YL)benzoic acid | 250683-76-2 | C12H15FN2O2 |
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1-(3,4,5-Trimethoxyphenyl)piperazine | 38869-07-7 | C13H20N2O3 |
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(3S)-3-methyl-1-phenylpiperazine | 337530-34-4 | C11H16N2 |
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Deacetyl Ketoconazole | 67914-61-8 | C24H26Cl2N4O3 |
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Tert-Butyl 4-(3-fluoro-2-nitrophenyl)piperazine-1-carboxylate | 915135-20-5 | C15H20FN3O4 |
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2-4-(4-fluorophenyl)piperazin-1-ylethan-1-ol | 90096-38-1 | C12H17FN2O |
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tert-Butyl 4-(3-Methoxy-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate | 1017782-79-4 | C16H23N3O5 |
Related Literature
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Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
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Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
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Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
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