O-methoxybenzoic acids and derivatives
O-Methoxybenzoic Acids and Derivatives are a class of organic compounds featuring an methoxyl group attached to the benzoic acid moiety. These compounds are widely utilized in various applications, including pharmaceuticals, agrochemicals, and industrial processes.
The O-methoxy group introduces unique reactivity to the parent benzoic acid structure, enhancing its solubility and lipophilicity. This modification can significantly impact the physicochemical properties and biological activities of the molecule. In drug discovery, these derivatives often exhibit improved pharmacokinetic profiles due to their altered hydrophilic-lipophilic balance.
Moreover, O-methoxybenzoic acids and their derivatives are crucial intermediates in the synthesis of a wide range of compounds, such as antioxidants, dyes, and polymer precursors. Their versatility makes them valuable tools in both academic research and industrial settings.
The presence of the methoxyl group can influence the compound's interaction with biomolecules, potentially affecting its binding affinity and selectivity. This feature renders these molecules suitable for probing enzyme mechanisms or serving as lead compounds in drug development efforts.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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2-Hydroxybenzyl alcohol; 2-Me ether, α-O-(2,3,6-trimethoxybenzoyl) | 81532-09-4 | C18H20O6 |
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nigerloxin | 477935-15-2 | C13H15NO5 |
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Fendlerinine B | 2098405-78-6 | C28H39NO8 |
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Asperterreusine B | 2270867-32-6 | C12H14O6 |
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BENZOIC ACID, 2,6-DIMETHOXY-, (2-METHOXYPHENYL)METHYL ESTER | 81532-10-7 | C17H18O5 |
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Frutescinon | 10401-21-5 | C15H12O4 |
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2,3-dimethoxy-6-hydroxybenzoic acid, phenylmethyl ester | 63147-21-7 | C16H16O5 |
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4-Hydroxy-2-methoxybenzoic acid | 90111-34-5 | C8H8O4 |
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Methyl 2-hydroxy-6-methoxybenzoate | 22833-69-8 | C9H10O4 |
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2-Methoxybenzoic acid | 579-75-9 | C8H8O3 |
Related Literature
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Felix Witte,Philipp Rietsch,Nithiya Nirmalananthan-Budau,Florian Weigert,Jan P. G?tze,Ute Resch-Genger,Siegfried Eigler,Beate Paulus Phys. Chem. Chem. Phys., 2021,23, 17521-17529
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Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
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Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
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James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
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