Nitrofurans are a class of antibiotics that have been widely used in veterinary medicine and human therapy for the treatment of various bacterial infections, particularly those caused by gram-negative bacteria. These compounds exhibit strong antibacterial activity due to their ability to inhibit key enzymes such as DNA gyrase and topoisomerase IV, leading to cell death. Nitrofurans are available in different formulations including tablets, capsules, injectables, and topical solutions. They are effective against a broad range of bacterial pathogens, making them versatile for diverse clinical applications. However, their use has been increasingly limited due to the emergence of drug-resistant strains and potential toxic side effects, such as liver toxicity and hemolytic anemia, particularly in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Therefore, careful monitoring and appropriate dosing are essential when prescribing nitrofurans.