Isoliquiritigenin, one of the key iso-flavonoids, is a natural compound found in plants such as licorice and soybeans. It possesses a diverse range of bioactivities including anti-inflammatory, antioxidant, and estrogenic properties. In traditional medicine, isoliquiritigenin has been used to treat various ailments due to its potential health benefits. Isoliquiritigenin works by modulating the immune system through the inhibition of pro-inflammatory cytokines. Additionally, it exhibits strong free radical scavenging activity, contributing to its antioxidant effects. Studies also indicate that this compound may have potential in managing menopausal symptoms and bone density issues due to its weak estrogenic activity. In pharmaceutical research, isoliquiritigenin is being explored for its anti-cancer properties, particularly in inhibiting tumor cell growth and promoting apoptosis. Its application as a natural remedy makes it an attractive candidate for developing new therapeutic agents with minimal side effects.