Ibogaine-type alkaloids are a class of psychoactive compounds derived primarily from the Tabernanthe iboga plant, native to West Central Africa. These naturally occurring secondary metabolites have gained significant attention for their potential therapeutic applications in addiction treatment and cognitive enhancement. Ibogaine, the archetypal member of this class, exhibits unique pharmacological properties by interacting with various neurotransmitter systems, including dopamine, noradrenaline, and serotonin receptors. Research suggests that ibogaine may help reduce withdrawal symptoms and cravings associated with substance abuse, particularly opiates and cocaine. However, due to its potent psychoactive effects and potential toxicity, careful clinical evaluation is essential for its safe use. Ibogaine-type alkaloids continue to be the subject of extensive scientific inquiry, aiming to unlock their full therapeutic potential while mitigating risks.