Hasubaban alkaloids are a class of natural products isolated from the roots and rhizomes of Hasubavana, an Asian medicinal plant belonging to the Apocynaceae family. These alkaloids exhibit significant pharmacological activities, particularly in anti-inflammatory, analgesic, and antimalarial effects. Structurally, they often feature complex nitrogen-containing heterocyclic rings, such as pyrrole, indole, and benzylisoquinoline rings, which contribute to their diverse biological properties. Research on hasubaban alkaloids has shown promising results in modulating immune responses and inhibiting inflammatory mediators, making them potential therapeutic agents for various inflammatory diseases. Additionally, certain derivatives have demonstrated efficacy against Plasmodium falciparum, the parasite responsible for causing severe malaria, indicating their potential in antimalarial drug development. Further studies are ongoing to explore the structural modifications of these alkaloids and to optimize their medicinal properties for clinical application.