Daphniphylline-type alkaloids are a class of natural products isolated from various plant species, particularly those belonging to the genus *Daphne*. These compounds exhibit a unique tricyclic skeleton characterized by a 6/5/3 ring system with a characteristic oxindole or pyrrolidine core. Notably, daphniphylline itself is one of the most studied members of this class due to its pharmacological activities. Research has shown that these alkaloids possess potential anti-tumor and anti-inflammatory properties. Additionally, they have garnered attention for their ability to modulate neuronal functions, suggesting possible applications in treating neurological disorders such as Alzheimer's disease. Due to their complex structure and diverse biological activities, daphniphylline-type alkaloids continue to be a subject of extensive chemical and medicinal research.