Cyclic peptides
Cyclic peptides are a class of bioactive molecules characterized by their ring-like structure, formed through the covalent linkage of amino acids. These peptides exhibit unique structural and functional properties due to their closed-ring conformation, which can provide increased stability against proteolytic degradation compared to linear peptides. Cyclic peptides play crucial roles in various biological processes, including cell signaling, enzyme inhibition, and target recognition. Their compact structure allows for the precise positioning of functional groups, leading to enhanced potency and selectivity. Due to their promising therapeutic potential, cyclic peptides are increasingly being investigated as novel drug candidates across different therapeutic areas such as oncology, inflammation, and infectious diseases. These peptides can be synthesized through solid-phase peptide synthesis (SPPS) or bio-orthogonal chemistry techniques, offering flexibility in structure design and modification.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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Vancomycin | 1404-90-6 | C66H75Cl2N9O24 |
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Pseudostellarin F (9CI) | 158335-67-2 | C38H56N8O10 |
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Pseudostellarin G | 156525-71-2 | C42H56N8O9 |
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Dianthin A (9CI) | 219808-29-4 | C33H43N7O8 |
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Glabrin C (9CI) | 226980-46-7 | C41H64N8O9 |
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Cyclo(L-isoleucyl-S-oxido-L-methionyl-L-leucyl-L-valyl-L-phenylalanyl-L-prolyl-L-leucyl-L-phenylalanyl) | 222527-67-5 | C51H76N8O9S |
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Benzenepropanamide, α-(dimethylamino)-N-[3-(1-methylethyl)-7-(1-methylpropyl)-5,8-dioxo-2-oxa-6,9-diazabicyclo[10.2.2]hexadeca-10,12,14,15-tetraen-4-yl]- (9CI) | 24532-77-2 | C31H42N4O4 |
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6,13,20-Trioxa-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.15,8.112,15]tetracosa-5(24),12(23),19(22)-triene-2,9,16-trione,7,14,21-trimethyl-4,11,18-tris(1-methylethyl)-, (1S,4S,7R,8S,11S,14R,15S,18S,21R)- | 131998-54-4 | C27H42N6O6 |
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Geninthiocin | 158792-27-9 | C50H49N15O15S |
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lissoclinamide 8 | 126452-98-0 | C38H43N7O5S2 |
Related Literature
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Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
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Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
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Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
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Doug Ogrin,Laura H. van Poppel,Simon G. Bott,Andrew R. Barron Dalton Trans., 2004, 3689-3694
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Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
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