Alpha-halocarboxylic acids
Alpha-halocarboxylic acids are a class of organic compounds characterized by the presence of a halogen atom, typically chlorine or bromine, attached to the α-carbon adjacent to the carboxyl group (-COOH). These compounds play significant roles in various chemical reactions and applications due to their reactivity.
Structurally, these acids have the general formula R-CHCl-COOH (for chlorine) or R-CHBr-COOH (for bromine), where R represents an alkyl or aryl substituent. Their synthetic preparation can be achieved through halogenation of carboxylic acid derivatives such as methyl ketones or aldehydes.
In chemical synthesis, alpha-halocarboxylic acids serve as versatile intermediates in organic reactions. They are often employed in the construction of more complex molecules via nucleophilic substitution at the α-position, leading to the formation of various functional groups. Additionally, these compounds can undergo rearrangement reactions and have applications in pharmaceuticals, agrochemicals, and polymers.
Due to their reactivity, careful handling is necessary when working with alpha-halocarboxylic acids to ensure safety and optimal results in synthetic processes.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
![]() |
2,2-difluoro-2-(trifluoromethoxy)acetic acid | 674-13-5 | C3HF5O3 |
![]() |
Acetic acid,2,2,2-trifluoro-, zinc salt (2:1) | 21907-47-1 | C4F6O4Zn |
![]() |
Dichlorofluoroacetic acid | 354-19-8 | C2HCl2FO2 |
![]() |
Propanoic acid,3-chloro-2,2,3-trifluoro- | 425-97-8 | C3H2ClF3O2 |
![]() |
triethylamine, trifluoroacetic acid | 454-49-9 | C8H16F3NO2 |
![]() |
Chlorofluoroacetic Acid | 471-44-3 | C2H2ClFO2 |
![]() |
2,2-dibromoacetic acid | 10024-50-7 | C2H2Br2O2 |
![]() |
Perfluoro-3,6,8-trioxadecanoic Acid | 151772-59-7 | C7HF13O5 |
![]() |
Acetic acid,2,2-dichloro-, ion(1-) | 13425-80-4 | C2HCl2O2 |
![]() |
Propanoic acid, 2,3,3-trichloro- | 20618-06-8 | C3H3Cl3O2 |
Related Literature
-
Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
-
Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
-
Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
-
Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
-
Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
Recommended suppliers
-
Shenzhen Jianxing Pharmaceutical Technology Co., Ltd.Factory Trade Brand reagentsCompany nature: Private enterprises
-
Hangzhou TSurgeX Pharmaceutical Technology Co., Ltd.Factory Trade Brand reagentsCompany nature: Private enterprises
-
Hangzhou Cedareal Technology Co., Ltd.Factory Trade Brand reagentsCompany nature: Private enterprises
-
Nantong Boya Environmental Protection Technology Co., LtdFactory Trade Brand reagentsCompany nature: Private enterprises
-
Hebei Liye chemical Co.,LtdFactory Trade Brand reagentsCompany nature: Private enterprises
Recommended products









