Cas no 99291-25-5 (Levodropropizine)
Levodropropizine is a non-opioid antitussive agent belonging to the phenylpiperazine class, primarily used for the symptomatic treatment of dry cough. Its mechanism of action involves peripheral inhibition of sensory airway receptors, reducing cough reflex sensitivity without central nervous system depression. Key advantages include a favorable safety profile, minimal sedative effects, and low potential for abuse compared to centrally acting antitussives like codeine. Levodropropizine is particularly suitable for pediatric and geriatric populations due to its reduced risk of respiratory depression. Clinical studies demonstrate efficacy in managing cough associated with upper respiratory tract infections and chronic bronchitis. The compound exhibits good oral bioavailability and rapid onset of action.
Levodropropizine structure
Product Name:Levodropropizine
CAS No:99291-25-5
MF:C13H20N2O2
MW:236.310103416443
MDL:MFCD00866852
CID:62050
PubChem ID:65859
Update Time:2025-07-21
Levodropropizine Chemical and Physical Properties
Names and Identifiers
-
- (S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
- Levodropropizine
- (2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
- Danka
- l-Dropropizine
- Levotuss
- LVDP
- Rapitux
- (S)-(-)-Dropropizine
- (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
- (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
- Levdropropizine
- (-)-Dropropizine
- Levodropropizina
- Levodropropizinum
- Levodropropizinum [INN-Latin]
- Levodropropizina [INN-Spanish]
- Levodropropizine [INN]
- DF 526
- 3O31P6T4G3
- S(-)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
- (-)-(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
- 1,2-Propanediol, 3-(4-phenyl-1-pi
- Levopront
- BRD-K83551379-001-02-6
- SCHEMBL29043
- CS-5212
- Levodropropizine (INN)
- DTXSID8023210
- DB12472
- CHEMBL1288810
- NS00096429
- L0339
- CAS-17692-31-8
- AKOS015889397
- CCG-266840
- NCGC00016730-01
- Q408131
- Salvituss
- AO-022/43512153
- Levopront (TN)
- 99291-25-5
- Levodropropizine impurity A
- 1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-, (2S)-
- DROPROPIZINE S-FORM [MI]
- Levodropropizine; (2S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
- Dropropizine S-form
- Q-100916
- AS-12822
- Dropropizine, (s)-
- F15098
- PTVWPYVOOKLBCG-ZDUSSCGKSA-N
- Z301111588
- LEVODROPROPIZINE [EP MONOGRAPH]
- Levodropropizine [INN:BAN]
- s4131
- HY-B1895
- D08119
- HMS3885B07
- 1,2-PROPANEDIOL, 3-(4-PHENYL-1-PIPERAZINYL)-, (S)-
- A845991
- LEVODROPROPIZINE [WHO-DD]
- MFCD00866852
- AC-8088
- UNII-3O31P6T4G3
- AC-2084
- dipropizine, (S)-isomer
- LEVODROPROPIZINE [MART.]
- NCGC00018230-01
- S-(-)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
- BCP9000850
- 1,2-Propanediol, 3-(4-phenylpiperazin-1-yl)-, S(-)-
- EN300-1718684
- CHEBI:82722
- NCGC00018230-06
- BCP0726000048
- DF-526
- STL559075
- BBL036696
- LEVODROPROPIZINE (EP MONOGRAPH)
- DTXCID003210
- Levodropropizina (INN-Spanish)
- Levdropropizina
- Levodropropizinum (INN-Latin)
- BRD-K83551379-001-01-8
- R05DB27
- LEVODROPROPIZINE (MART.)
-
- MDL： MFCD00866852
- Inchi： 1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1
- InChI Key： PTVWPYVOOKLBCG-ZDUSSCGKSA-N
- SMILES： O[C@H](CO)CN1CCN(C2C=CC=CC=2)CC1
Computed Properties
- Exact Mass: 236.15200
- Monoisotopic Mass: 236.152
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 17
- Rotatable Bond Count: 4
- Complexity: 212
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 46.9
- XLogP3: 0.6
Experimental Properties
- Color/Form: White crystal powder
- Density: 1.168
- Melting Point: 103.0 to 107.0 deg-C
- Boiling Point: 412.7 °C at 760 mmHg
- Flash Point: 220.9 °C
- Refractive Index: 1.576
- PSA: 46.94000
- LogP: 0.16470
Levodropropizine Security Information
-
Symbol:
- Prompt：warning
- Hazard Statement： H302
- Warning Statement： P264-P270-P301+P312+P330-P501
- Hazardous Material transportation number：NONH for all modes of transport
- RTECS：TZ1075100
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Levodropropizine Customs Data
- HS CODE：2933599090
- Customs Data：
China Customs Code:
2933599090Overview:
2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Levodropropizine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | L0420000 |
Levodropropizine |
99291-25-5 | European Pharmacopoeia (EP) Reference Standard | ￥2654.27 | 2022-02-23 | ||
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | L870493-100g |
Levodropropizine |
99291-25-5 | 99% | 100g |
1,260.00 | 2021-05-17 | |
| Fluorochem | 211612-250mg |
S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol |
99291-25-5 | 95% | 250mg |
￡239.00 | 2022-03-01 | |
| Fluorochem | 211612-1g |
S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol |
99291-25-5 | 95% | 1g |
￡598.00 | 2022-03-01 | |
| Fluorochem | 211612-5g |
S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol |
99291-25-5 | 95% | 5g |
￡1793.00 | 2022-03-01 | |
| TRC | D681500-50mg |
(S)-(-)-Dropropizine |
99291-25-5 | 50mg |
$ 103.00 | 2023-09-07 | ||
| TRC | D681500-100mg |
(S)-(-)-Dropropizine |
99291-25-5 | 100mg |
$ 161.00 | 2023-09-07 | ||
| TRC | D681500-1g |
(S)-(-)-Dropropizine |
99291-25-5 | 1g |
$ 546.00 | 2023-09-07 | ||
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci14670-50mg |
Levodropropizine |
99291-25-5 | 98% | 50mg |
￥617.00 | 2023-09-09 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | S43220-100mg |
Levodropropizine |
99291-25-5 | 100mg |
￥36.0 | 2021-09-07 |
Levodropropizine Suppliers
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier
(CAS:99291-25-5)Levodropropizine
Order Number:sfd17116
Stock Status:in Stock
Quantity:200kg
Purity:99%
Pricing Information Last Updated:Friday, 19 July 2024 14:37
Price ($):discuss personally
Email:[email protected]
Amadis Chemical Company Limited
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(CAS:99291-25-5)Levodropropizine
Order Number:A845991
Stock Status:in Stock
Quantity:100g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 07:07
Price ($):171.0
Email:[email protected]
Shanghai Jinhuan Chemical CO., LTD.
Gold Member
Audited Supplier
(CAS:99291-25-5)Levodropropizine
Order Number:JH011
Stock Status:in Stock
Quantity:25kg
Purity:98.00%
Pricing Information Last Updated:Monday, 8 January 2024 17:37
Price ($): negotiated
Email:[email protected]
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier
(CAS:99291-25-5)左羥丙哌嗪
Order Number:LE2599797
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:41
Price ($):discuss personally
Email:[email protected]
Levodropropizine Related Literature
-
Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
-
S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
-
Ni-Na Sun,Fengli Qu,Xiaobing Zhang,Shufang Zhang,Jinmao You Analyst, 2015,140, 1827-1831
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P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
-
Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789
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