Cas no 98136-52-8 (2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)-)

2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- is a brominated pyrimidine derivative with potential utility in organic synthesis and pharmaceutical research. Its structure features reactive bromine substituents, including a dibromomethyl group, which enhance its versatility as a building block for further functionalization. The compound’s electron-deficient pyrimidine core makes it suitable for nucleophilic substitution reactions, while the bromine atoms offer sites for cross-coupling methodologies, such as Suzuki or Buchwald-Hartwig reactions. This compound may serve as a key intermediate in the development of bioactive molecules, particularly in medicinal chemistry for targeting heterocyclic scaffolds. Its stability and defined reactivity profile contribute to its applicability in controlled synthetic pathways.
2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- structure
98136-52-8 structure
Product Name:2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)-
CAS No:98136-52-8
MF:C5H4Br3N3
MW:345.817358016968
CID:4372635
PubChem ID:23657891
Update Time:2025-05-30

2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- Chemical and Physical Properties

Names and Identifiers

    • 2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)-
    • 5-bromo-4-(dibromomethyl)-2-pyrimidinylamine
    • AN-584/43409804
    • 5-bromo-4-(dibromomethyl)pyrimidin-2-amine
    • 98136-52-8
    • Inchi： 1S/C5H4Br3N3/c6-2-1-10-5(9)11-3(2)4(7)8/h1,4H,(H2,9,10,11)
    • InChI Key： RTKZAJDBCOUJIP-UHFFFAOYSA-N
    • SMILES： C1(C(Br)Br)C(Br)=CN=C(N)N=1

Computed Properties

  • Exact Mass: 344.793
  • Monoisotopic Mass: 342.796
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 1
  • Complexity: 132
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 51.8A^2
  • XLogP3: 2

2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI HAO HONG Biomedical Technology Co., Ltd.
1657814-1g
5-Bromo-4-(dibromomethyl)pyrimidin-2-amine
 98136-52-8 98%
1g
 ￥7391.00 2024-04-23

2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- Related Literature

Additional information on 2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)-

Recent Advances in the Study of 2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- (CAS: 98136-52-8)

The compound 2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- (CAS: 98136-52-8) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its unique structural properties and potential therapeutic applications. This research brief aims to synthesize the latest findings related to this compound, focusing on its synthesis, biological activity, and potential applications in drug development.

Recent studies have highlighted the role of 2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- as a key intermediate in the synthesis of novel heterocyclic compounds. Its brominated structure makes it a valuable precursor for the development of bromine-containing pharmaceuticals, which are increasingly recognized for their bioactivity. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy in inhibiting specific enzymatic pathways involved in inflammatory responses, suggesting potential applications in anti-inflammatory drug development.

In addition to its pharmacological potential, advancements in the synthetic methodologies for 2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- have been reported. A team of researchers from the University of Cambridge recently developed a more efficient and environmentally friendly synthesis route, reducing the use of hazardous reagents while maintaining high yield and purity. This breakthrough, published in Green Chemistry, could facilitate larger-scale production and further exploration of its applications.

Furthermore, computational studies have provided insights into the molecular interactions of this compound with biological targets. Molecular docking simulations revealed strong binding affinities to certain protein kinases, indicating its potential as a kinase inhibitor. These findings, coupled with in vitro assays, underscore the compound's promise in targeted cancer therapies.

Despite these promising developments, challenges remain in optimizing the pharmacokinetic properties of 2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)-. Current research is focused on structural modifications to enhance its bioavailability and reduce potential toxicity. Collaborative efforts between academic institutions and pharmaceutical companies are underway to translate these findings into clinical applications.

In conclusion, 2-Pyrimidinamine, 5-bromo-4-(dibromomethyl)- (CAS: 98136-52-8) represents a compelling area of research in chemical biology. Its diverse applications, from anti-inflammatory agents to potential anticancer drugs, coupled with recent synthetic advancements, position it as a compound of significant interest for future drug discovery efforts. Continued research is expected to further elucidate its mechanisms of action and therapeutic potential.

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