• 1. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 2. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 3. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
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  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 5. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Diphenylethers

Comprehensive Overview of 4-(2-Nitro-4-(trifluoromethyl)phenoxy)phenylboronic Acid (CAS No. 957062-58-7)

4-(2-Nitro-4-(trifluoromethyl)phenoxy)phenylboronic Acid (CAS No. 957062-58-7) is a specialized boronic acid derivative widely recognized for its applications in organic synthesis, pharmaceutical research, and material science. This compound features a unique molecular structure combining a nitro group, a trifluoromethyl group, and a phenoxy linker, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions. Researchers and industries value its role in constructing complex biaryl structures, which are pivotal in drug discovery and advanced material development.

The growing demand for 4-(2-Nitro-4-(trifluoromethyl)phenoxy)phenylboronic Acid is driven by its utility in designing targeted therapeutics and functional materials. With the rise of personalized medicine and green chemistry, this compound aligns with trends emphasizing sustainable synthesis and high-efficiency catalysts. Its boronic acid moiety enables selective binding to biomolecules, making it a candidate for protease inhibitors and sensor technologies. Recent studies highlight its potential in cancer research, particularly in modulating protein-protein interactions.

From a technical perspective, 957062-58-7 exhibits stability under controlled conditions, though it requires handling in inert atmospheres due to its sensitivity to moisture. Analytical techniques like HPLC, NMR, and mass spectrometry are routinely employed to verify its purity, which is critical for high-yield reactions. The compound’s electron-withdrawing groups enhance its reactivity in palladium-catalyzed couplings, a feature exploited in synthesizing fluorescent dyes and OLED materials.

In the context of AI-driven drug discovery, 4-(2-Nitro-4-(trifluoromethyl)phenoxy)phenylboronic Acid has garnered attention for its compatibility with machine learning models predicting molecular interactions. Its structural motifs are frequently queried in chemical databases, reflecting its relevance in fragment-based drug design. Additionally, the compound’s trifluoromethyl group contributes to metabolic stability, a sought-after property in pharmacokinetic optimization.

Environmental and regulatory considerations further underscore its importance. As industries shift toward REACH-compliant and halogen-free alternatives, the judicious use of 957062-58-7 in catalytic cycles minimizes waste generation. Its role in C-H activation methodologies also supports atom-economical transformations, resonating with circular economy principles.

Looking ahead, innovations in continuous flow chemistry and electrochemical synthesis are expected to expand the applications of 4-(2-Nitro-4-(trifluoromethyl)phenoxy)phenylboronic Acid. Its integration into automated synthesis platforms could streamline the production of next-generation APIs and smart materials. For researchers, understanding its structure-activity relationships remains a key focus, particularly in structure-based drug design projects targeting orphan diseases.

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