Cas no 957035-24-4 (6-Chloroimidazo1,2-Apyridine Hydrochloride)

6-Chloroimidazo[1,2-a]pyridine Hydrochloride is a heterocyclic compound featuring a chloro-substituted imidazopyridine core, rendered as a hydrochloride salt for enhanced stability and solubility. This intermediate is widely utilized in pharmaceutical and agrochemical research, particularly in the synthesis of bioactive molecules. Its fused bicyclic structure offers versatile reactivity, enabling functionalization at multiple sites for tailored modifications. The hydrochloride form ensures improved handling and storage characteristics. Key applications include the development of antimicrobial, antiviral, and CNS-targeting agents. The compound’s high purity and well-defined chemical properties make it a reliable building block for medicinal chemistry and drug discovery efforts.
6-Chloroimidazo1,2-Apyridine Hydrochloride structure
957035-24-4 structure
Product Name:6-Chloroimidazo1,2-Apyridine Hydrochloride
CAS No:957035-24-4
MF:C7H6Cl2N2
MW:189.041939258575
MDL:MFCD09475876
CID:857687
PubChem ID:44118778
Update Time:2025-05-26

6-Chloroimidazo1,2-Apyridine Hydrochloride Chemical and Physical Properties

Names and Identifiers

    • 6-Chloroimidazo[1,2-a]pyridine hydrochloride
    • 6-Chloroimidazo[1,2-a]pyridine, HCl
    • 6-chloroimidazo[1,2-a]pyridine;hydrochloride
    • 6-CHLOROH-IMIDAZO[1,2-A]PYRIDINE HCL
    • CS-0205698
    • J-518610
    • 6-Chloroimidazo[1,2-a]pyridinehydrochloride
    • MFCD09475876
    • DTXSID80656983
    • PS-8427
    • A845388
    • 6-Chloroimidazo[1,2-a]pyridine--hydrogen chloride (1/1)
    • 6-Chloroimidazo[1,2-a]pyridine HCl
    • SY128104
    • AKOS015892415
    • 6-chloroH-imidazo[1,2-a]pyridine hydrochloride
    • 957035-24-4
    • 6-Chloroimidazo1,2-Apyridine Hydrochloride
    • MDL: MFCD09475876
    • Inchi: 1S/C7H5ClN2.ClH/c8-6-1-2-7-9-3-4-10(7)5-6;/h1-5H;1H
    • InChI Key: TZDHZKWGTHQGTI-UHFFFAOYSA-N
    • SMILES: ClC1C=CC2=NC=CN2C=1.Cl

Computed Properties

  • Exact Mass: 187.99100
  • Monoisotopic Mass: 187.9908036g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 0
  • Complexity: 129
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: nothing
  • Topological Polar Surface Area: 17.3?2

Experimental Properties

  • PSA: 17.30000
  • LogP: 2.78970

6-Chloroimidazo1,2-Apyridine Hydrochloride Customs Data

  • HS CODE:2933990090
  • Customs Data:

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Additional information on 6-Chloroimidazo1,2-Apyridine Hydrochloride

6-Chloroimidazo[1,2-A]pyridine Hydrochloride (CAS 957035-24-4): A Comprehensive Overview

6-Chloroimidazo[1,2-A]pyridine Hydrochloride (CAS 957035-24-4) is a heterocyclic organic compound with significant applications in pharmaceutical research and material science. This compound, characterized by its imidazo[1,2-A]pyridine core and a chloro substituent at the 6-position, has garnered attention due to its versatile chemical properties and potential therapeutic uses. Researchers and industry professionals frequently search for terms like "6-Chloroimidazo[1,2-A]pyridine Hydrochloride synthesis", "CAS 957035-24-4 applications", and "imidazo[1,2-A]pyridine derivatives", reflecting its relevance in modern chemistry.

The structural uniqueness of 6-Chloroimidazo[1,2-A]pyridine Hydrochloride lies in its fused bicyclic system, which enhances its stability and reactivity. This makes it a valuable intermediate in the development of novel pharmaceutical agents, particularly in the fields of anti-inflammatory and central nervous system (CNS) therapeutics. Recent studies have explored its role as a precursor for kinase inhibitors, a hot topic in cancer research. The compound's hydrochloride salt form further improves its solubility, a critical factor for drug formulation.

In the context of green chemistry and sustainable synthesis, CAS 957035-24-4 has been investigated for eco-friendly production methods. With growing interest in AI-driven drug discovery, computational models often utilize this scaffold to predict bioactivity, aligning with trends like "machine learning in medicinal chemistry". Additionally, its photophysical properties have sparked research in organic electronics, addressing demands for OLED materials and fluorescent probes.

Quality control of 6-Chloroimidazo[1,2-A]pyridine Hydrochloride involves advanced analytical techniques such as HPLC and NMR spectroscopy, ensuring compliance with Good Manufacturing Practice (GMP) standards. Suppliers often highlight high-purity grades (>98%) to meet the stringent requirements of preclinical studies. The compound's storage conditions (typically 2-8°C under inert atmosphere) are another frequently searched topic, emphasizing its sensitivity to moisture and light.

Beyond pharmaceuticals, imidazo[1,2-A]pyridine derivatives are gaining traction in agrochemicals and veterinary medicine, with patents citing CAS 957035-24-4 as a key intermediate. Its structure-activity relationship (SAR) studies are widely published, catering to queries like "imidazo[1,2-A]pyridine scaffold optimization". As regulatory agencies emphasize REACH compliance, proper documentation of this compound's safety data sheets (SDS) remains crucial for industrial applications.

The global market for 6-Chloroimidazo[1,2-A]pyridine Hydrochloride reflects its cross-disciplinary importance, with custom synthesis services and bulk procurement options being highly sought after. Recent publications on metal-catalyzed functionalization of its core structure have further expanded its utility in catalysis research. For researchers, understanding its crystallography data (available in Cambridge Structural Database) aids in co-crystal engineering – a trending area in solid-state chemistry.

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