• 1. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 2. Distributed research: a new paradigm for undergraduate research and global problem solving?
  Bruce Parkinson Energy Environ. Sci., 2010,3, 509-511
• 3. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 4. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 5. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064

2-(3-Methyl-4-nitro-1H-pyrazol-1-yl)propanoic Acid (CAS No. 956950-97-3): An Overview of Its Properties, Applications, and Recent Research

2-(3-Methyl-4-nitro-1H-pyrazol-1-yl)propanoic Acid (CAS No. 956950-97-3) is a unique compound that has garnered significant attention in the fields of organic chemistry, medicinal chemistry, and pharmaceutical research. This compound, often referred to by its systematic name, is a derivative of pyrazole with a nitro group and a methyl group attached to the pyrazole ring, and a propanoic acid moiety. The combination of these functional groups imparts distinct chemical and biological properties that make it a valuable candidate for various applications.

The structure of 2-(3-methyl-4-nitro-1H-pyrazol-1-yl)propanoic acid is characterized by its pyrazole ring, which is a five-membered heterocyclic compound with two nitrogen atoms. The presence of the nitro group at the 4-position of the pyrazole ring enhances the compound's electron-withdrawing properties, while the methyl group at the 3-position provides steric hindrance and additional stability. The propanoic acid moiety, attached to the 1-position of the pyrazole ring, introduces carboxylic acid functionality, which can participate in various chemical reactions and interactions.

In terms of its physical properties, 2-(3-methyl-4-nitro-1H-pyrazol-1-yl)propanoic acid is a solid at room temperature with a melting point ranging from 180 to 185°C. It is slightly soluble in water but more soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO). The compound's solubility characteristics make it suitable for use in various experimental conditions and formulations.

The chemical reactivity of 2-(3-methyl-4-nitro-1H-pyrazol-1-yl)propanoic acid is influenced by its functional groups. The carboxylic acid group can undergo esterification, amide formation, and other reactions typical of carboxylic acids. The nitro group can be reduced to an amino group under appropriate conditions, which can significantly alter the compound's properties and biological activity. Additionally, the pyrazole ring itself can participate in various substitution reactions, making this compound versatile for synthetic chemistry.

In the realm of pharmaceutical research, 2-(3-methyl-4-nitro-1H-pyrazol-1-yl)propanoic acid has shown promise as a lead compound for drug discovery. Recent studies have explored its potential as an anti-inflammatory agent due to its ability to inhibit cyclooxygenase (COX) enzymes, which are key targets in the treatment of inflammatory diseases. The compound's anti-inflammatory properties have been evaluated in both in vitro and in vivo models, demonstrating significant efficacy.

Beyond its anti-inflammatory potential, 2-(3-methyl-4-nitro-1H-pyrazol-1-yl)propanoic acid has also been investigated for its antiviral activity. Research has shown that it can inhibit the replication of certain viruses by interfering with viral protein synthesis or assembly processes. This makes it a potential candidate for the development of antiviral drugs against emerging viral threats.

The toxicological profile of 2-(3-methyl-4-nitro-1H-pyrazol-1-yl)propanoic acid has been studied to ensure its safety for pharmaceutical applications. In vitro cytotoxicity assays have indicated that the compound exhibits low toxicity towards mammalian cells at therapeutic concentrations. However, further studies are needed to fully understand its long-term effects and potential side effects in humans.

In conclusion, 2-(3-methyl-4-nitro-1H-pyrazol-1-yl)propanoic acid (CAS No. 956950-97-3) is a multifaceted compound with promising applications in pharmaceutical research. Its unique chemical structure and biological activities make it an attractive candidate for further investigation and development as a therapeutic agent. Ongoing research continues to uncover new insights into its mechanisms of action and potential therapeutic uses, contributing to advancements in drug discovery and medicinal chemistry.

• 1207877-93-7(1-Tert-butyl-4-nitro-1H-pyrazole-3-carboxylic acid)
• 1006435-72-8(2-Methyl-2-(3-methyl-4-nitro-1H-pyrazol-1-YL)propanoic acid)
• 345637-69-6((3,5-Dimethyl-4-nitro-1H-pyrazol-1-yl)acetic Acid)
• 956204-54-9((3-methyl-4-nitro-1H-pyrazol-1-yl)acetic acid)
• 1393101-99-9(2-methyl-2-(5-methyl-4-nitro-1H-pyrazol-1-yl)propanoic acid)
• 1393102-00-5(1-(3-methyl-4-nitro-1H-pyrazol-1-yl)cyclopropanecarboxylic acid)
• 1374829-43-2(2-methyl-2-(3-methyl-4-nitro-pyrazol-1-yl)propanamide)
• 1001611-09-1((5-Methyl-4-nitro-1H-pyrazol-1-yl)acetic acid)
• 956396-51-3(3-(3-Methyl-4-nitro-1H-pyrazol-1-yl)propanoic acid)
• 887408-84-6(2-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)propanoic Acid)