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  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 2. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Primary amines

Introduction to 5-(Methoxymethyl)-1,2-oxazol-3-amine (CAS No. 95312-49-5)

5-(Methoxymethyl)-1,2-oxazol-3-amine, identified by the Chemical Abstracts Service Number (CAS No.) 95312-49-5, is a significant compound in the realm of pharmaceutical chemistry and bioorganic synthesis. This heterocyclic amine derivative features a unique structural framework that has garnered considerable attention from researchers due to its versatile reactivity and potential applications in drug development. The compound belongs to the oxazole class, characterized by a five-membered ring containing one oxygen atom and two carbon atoms, which is further functionalized with an amine group and a methoxymethyl substituent. Such structural motifs are often exploited in medicinal chemistry for their ability to interact with biological targets in specific ways.

The methoxymethyl (methyl ether) group attached to the oxazole ring introduces a degree of lipophilicity and electronic modulation, which can influence the compound's solubility, metabolic stability, and binding affinity to biological receptors. This feature makes 5-(Methoxymethyl)-1,2-oxazol-3-amine a valuable scaffold for designing novel pharmacophores. In recent years, there has been growing interest in oxazole derivatives due to their demonstrated efficacy in various therapeutic areas, including anti-inflammatory, antimicrobial, and anticancer applications.

Recent advancements in synthetic methodologies have enabled more efficient and scalable production of 5-(Methoxymethyl)-1,2-oxazol-3-amine, facilitating its exploration in preclinical and clinical studies. The compound's reactivity allows for further derivatization, enabling chemists to modify its properties tailored to specific biological targets. For instance, the amine functionality can be readily coupled with carboxylic acids via amide bond formation, a common strategy in drug molecule construction. This adaptability has positioned 5-(Methoxymethyl)-1,2-oxazol-3-amine as a building block for libraries of compounds designed for high-throughput screening (HTS) campaigns.

One of the most compelling aspects of 5-(Methoxymethyl)-1,2-oxazol-3-amine is its potential as an intermediate in the synthesis of more complex molecules. The oxazole ring itself is known for its stability and ability to engage in hydrogen bonding interactions, making it a privileged structure in drug design. Additionally, the presence of both polar (amine) and non-polar (methyl ether) functional groups enhances its compatibility with diverse biochemical environments. Such characteristics are particularly advantageous when designing molecules intended for oral administration or intravenous delivery.

In the context of current research trends, 5-(Methoxymethyl)-1,2-oxazol-3-amine has been investigated for its role in modulating enzyme activity. Oxazole derivatives have shown promise as inhibitors of certain kinases and proteases implicated in diseases such as cancer and inflammatory disorders. The methoxymethyl group may serve as a pharmacophoric element that enhances binding affinity by participating in hydrophobic interactions or by influencing the conformational flexibility of the molecule. Furthermore, computational studies have suggested that this compound could exhibit favorable pharmacokinetic properties, including adequate absorption, distribution, metabolism, excretion (ADME), and low toxicity.

The synthesis of 5-(Methoxymethyl)-1,2-oxazol-3-amine typically involves multi-step organic transformations starting from commercially available precursors. A common route includes the formation of an oxazole core followed by functionalization at the 3-position with an amine group and subsequent methylation at the 5-position with a methoxymethyl group. Advances in catalytic systems have allowed for more sustainable synthetic pathways, reducing waste generation and improving yields. These developments align with broader industry efforts to adopt greener chemistry principles.

From a medicinal chemistry perspective, 5-(Methoxymethyl)-1,2-oxazol-3-amine exemplifies how structural diversity can be leveraged to discover novel therapeutics. Its unique combination of functional groups provides multiple points of interaction with biological targets, potentially leading to synergistic effects or improved selectivity over existing treatments. As computational biology tools become increasingly sophisticated, virtual screening approaches are being employed to identify derivatives of this compound with enhanced biological activity. Such high-throughput virtual screening methods have accelerated the drug discovery process significantly.

The safety profile of 5-(Methoxymethyl)-1,2-oxazol-3-amine is another critical consideration in its development as a pharmaceutical candidate. Preliminary toxicological studies have indicated that the compound exhibits low acute toxicity when tested in vitro and in animal models under controlled conditions. However, comprehensive safety assessments are necessary before it can be considered for human trials. These assessments will evaluate potential long-term effects on organ systems such as the liver or kidneys and identify any mutagenic or carcinogenic risks associated with chronic exposure.

In conclusion,5-(Methoxymethyl)-1,2-Oxazol - 3 - amine (CAS No . 95312 - 49 - 5) represents an intriguing chemical entity with broad applications across pharmaceutical research . Its structural features , synthetic accessibility , and promising biological activity make it an attractive candidate for further investigation . As research continues , this compound may contribute valuable insights into developing new therapeutic agents targeting various diseases . The integration of cutting-edge synthetic techniques , computational modeling , and experimental validation underscores its potential as a key intermediate or lead molecule in future drug discovery endeavors .

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