• 1. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 2. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 3. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 5. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768

Comprehensive Overview of (2-Methyl-1H-indol-6-yl)boronic acid (CAS No. 948593-01-9)

(2-Methyl-1H-indol-6-yl)boronic acid (CAS No. 948593-01-9) is a specialized boronic acid derivative widely utilized in organic synthesis, pharmaceutical research, and material science. This compound belongs to the indole boronic acid family, a class of molecules known for their versatility in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern drug discovery and medicinal chemistry. With the increasing demand for heterocyclic building blocks, this compound has gained significant attention due to its unique structural features and reactivity.

The molecular structure of (2-Methyl-1H-indol-6-yl)boronic acid combines an indole scaffold with a boronic acid functional group, making it a valuable intermediate for constructing complex molecules. Researchers frequently employ it in the synthesis of biologically active compounds, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory agents. Its CAS No. 948593-01-9 is often searched in databases like SciFinder and Reaxys, reflecting its relevance in high-throughput screening and combinatorial chemistry.

In recent years, the compound has been linked to advancements in cancer therapeutics, with studies exploring its role as a precursor for kinase inhibitors and apoptosis inducers. The 2-methylindole moiety enhances metabolic stability, a critical factor in drug design optimization. Additionally, its boronic acid group enables precise C-C bond formation, aligning with the pharmaceutical industry’s push for green chemistry and atom-efficient reactions.

From a commercial perspective, (2-Methyl-1H-indol-6-yl)boronic acid is supplied by leading fine chemical manufacturers under stringent quality control standards. Its applications extend to OLED materials and organic electronics, where indole derivatives contribute to light-emitting efficiency. As the demand for tailor-made intermediates grows, this compound’s synthetic flexibility positions it as a key player in custom synthesis projects.

Environmental and regulatory considerations are also paramount. The compound’s low toxicity profile and compatibility with sustainable solvents (e.g., water or ethanol) make it attractive for eco-friendly synthesis. Laboratories often prioritize it for Pd-catalyzed reactions due to its high purity (>98%) and consistent batch-to-batch reproducibility, addressing the industry’s need for reliable reagents.

Future research directions may explore its potential in proteolysis-targeting chimeras (PROTACs) and bioconjugation techniques, areas trending in biopharmaceutical innovation. With its dual functionality, CAS No. 948593-01-9 remains a focal point for academic-industrial collaborations, bridging gaps between small-molecule development and therapeutic breakthroughs.

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