Cas no 94790-37-1 (HBTU)

HBTU (O-(1-H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) is a highly efficient and versatile coupling reagent in peptide synthesis, offering rapid formation of amide bonds with excellent yields. Its high solubility and stability facilitate easy handling and minimize reaction times, making it an essential tool for researchers in the field of organic chemistry and biochemistry.

HBTU structure

Product Name:HBTU

CAS No:94790-37-1

MF:C₁₁H₁₆F₆N₅OP

MW:379.241823196411

MDL:MFCD00075445

CID:61748

PubChem ID:57647025

Update Time:2025-11-11

HBTU Chemical and Physical Properties

Names and Identifiers

- O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate
- HBTU
- O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluoro-phosphate
- O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluorophosphate
- 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate
- O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
- HBTU [Coupling Reagent for Peptide]
- 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide
- [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium,hexafluorophosphate
- HBTU O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluorophosphate
- O-(Benzotriazol-1-yl)-N,N,N',N'-tetraMethyluroniuM Hexafluorophosphate
- O-(Benzotriazol-1-yl)-N,N,N',N'-tetraMethyluroniuM Hexafluorophosphate [Coupling Reagent for Peptide]
- 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Hexafluorophosphate
- o-Benzotriazol-1-yl-tetramethyluronium hexafluorophosphate
- 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophospha
- o-benzotriazole-n,n,n',n'-tetramethyluronium hexafluorophosphate
- O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluoro-phosphate
- SB40717
- DTXSID101335774
- 2-(1H)-benzotriazol-1-yl-1,1,3,3-tetramethyluronium hexafluorophosphate
- 2-(benzotriazol-1-yl)-N,N,N',N'-tetramethyl-uronium hexafluoro phosphate
- 2-(1H-benzotriazole-1-yl)-1, 1,3,3-tetramethyluronium hexafluorophosphate
- B1657
- O-benzotriazol-1-yl-N, N, N', N'-tetramethyluronium hexafluorophosphate
- 2-(1h-benzotriazole-1-yl)-1,1,3,3,-tetramethyluronium hexafluorophosphate
- Z210803824
- 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyl-uronium hexafluorophosphate
- O-benzotriazol-1-yl-N,N,N',N'-tetramethyl-uronium hexa-fluoro-phosphate
- O-benzotriazol-l-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate
- O-(benzotriazol-1-yl)-N
- MFCD00075445
- benzotriazol-1 -yl-(bis-dimethylamino-methylene)-oxonium hexafluoro phosphate
- O-benzotriazole-1-yl-N,N,N', N'-tetramethyluronium hexafluorophosphate
- O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyl-uronium hexafluorophosphate
- Z-1021
- (benzotriazol-1-yloxy-dimethylamino-methylene)-dimethyl-ammonium hexafluorophosphate
- AKOS001288036
- 2-[1H-benzotriazole-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate
- o-(benzotriazol-1-yl)-n,n,n'n,'-tetramethyluroniumhexafluorophosphate
- Q19787025
- [2-(1H)-benzotriazole-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate
- 2-(1h-benzo[d][1,2,3]triazol-1-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate(v)
- [benzotriazol-1-yloxy(dimethylamino)methylene]-dimethyl-ammonium hexafluorophosphate
- 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophospate
- N,N, N',N'-tetramethyl-O-(1H-benzotriazol-1-yl)-uronium hexafluorophosphate
- O-(benzotriazol-1yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
- N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methylmethanaminium hexafluorophosphate
- 2(1h-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate
- O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluroniumhexafluoro-phosphate
- O-benzotriazol-1-yl-N,N,N',N'-tetramethyl-uroniumhexafluorophosphate
- O-benzotriazol-1-yl-N,N, N',N'-tetramethyluronium hexafluoro-phosphate
- HBTU, >=98.0% (T)
- O-Benzotriazol-1-yl-N,N,N',N'-tetra-methyluronium hexafluorophosphate
- O-benzotriazole-N,N,N',N'-tetramethyluroniumhexafluorophosphate
- O-benzotriazol-1-yl-N,N,N',N'-tetramethyluroniumhexa-fluorophosphate
- N,N,N',N'-Tetramethyl-O-(benzotriazol-1-yl)uronium Hexafluorophosphate
- O-benzotriazol-1-yl-N,N,N',N'-tetramethyl-uronium hexafluoro-phosphate
- 0-benzotriazol-1-yl-N,N,N',N'-tetramethyluroniumhexafluorophosphate
- O-benzotriazol-1-yl-N,N, N',N'-tetramethyluronium hexafluorophosphate
- 625384-22-7
- N,N,N',N'-tetramethyl-O-(1H-benzotriazol-1-yl)uroniumhexafluorophosphate
- O-benzotriazole-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate
- O-(1H-benzotriazol-1-yl)-1
- [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium;hexafluorophosphate
- O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate salt
- [[2H-benzotriazol-4-yl(methyl)amino]-methoxy-methylene]-dimethyl-ammonium; fluoro-dioxido-oxo-$l^{5}-phosphane
- O-Benzotriazole-N,N,N',N',-tetramethyluronium hexafluorophosphate
- O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophos-phate
- O-benzotriazol-1-ylN,N,N',N'-tetramethyluronium hexafluorophosphate
- 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluoro-phosphate
- AS-11820
- O-benzotriazol-1-yl-N,N,N',N'-tetramethyl-uronium hexafluorophosphate
- 0-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluroniumhexafluorophosphate
- benzotriazol-1-yl-[bis(dimethylamino)methylene]oxonium hexafluorophosphate
- HBTU [O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluoro-phosphate]
- AM83826
- N,N,N',N'-tetramethyl-O-(1H-benzotriazol-1-yl)-uronium hexafluorophosphate
- O-benzotriazol-1yl-N,N,N',N'-tetramethyluronium hexafluorophosphate
- 0-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
- o-(1h-benzotriazol-1-yl)-n,n,n'n'-tetramethyluronium hexafluorophosphate
- 0-Benzotriazol-1-yl-tetramethyluronium hexafluorophosphate
- 0-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate
- O-benzotriazole-1-yl-N,N,N',N'-tetramethyl-uronium hexafluorophosphate
- O-benzotriazol-1-yl-N,N,N', N'-tetramethyluronium hexafluorophosphate
- o-(benzotriazole-1-yl)-n,n,n',n'-tetramethyluronium hexafluorophosphate
- O-benzotriazol-1 yl-N,N,N',N'-tetramethyluronium hexafluorophosphate
- O-(Benzotriazol-1-yl)-N,N,N inverted exclamation mark ,N inverted exclamation mark -tetramethyluronium Hexafluorophosphate (HBTU)
- 2-(1H-benzotriazole-1-yl)-1
- 2-(1H-benzotriazole-1-yl)1,1,3,3-tetramethyluronium hexafluorophosphate
- benzotriazol-1-yl-(bis-dimethylamino-methylene)-oxonium hexafluoro phosphate
- [(benzotriazol-1-yloxy)-dimethylamino-methylene]-dimethyl-ammonium hexafluoro phosphate
- o-(benzotriazol-1-yl)-n,n, n',n'-tetramethyluronium hexafluorophosphate
- O-benzotriazol-1-yl-N,N, N',N'-tetramethyluronium hexafluorophos-phate
- SY001899
- AC-4494
- 2-benzotriazol-1-yl-n,n,n',n'-tetramethyluronium hexafluorphosphate
- O-(benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate
- 2-(1h-benzotriazol-1-yl)-tetramethyluronium hexafluorophosphate
- AKOS015999572
- O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HBTU)
- 94790-37-1
- O-(1-benzotriazolyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
- 2-(1H-benzo[1,2,3]triazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate
- o-benzotriazol-1-yl-n,n,n',n',-tetramethyluronium hexafluorophosphate
- O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophospate
- O-Benzotriazol-N,N,N', N'-tetramethyluronium hexafluorophosphate
- o-(benzotriazol-1-yl)-n,n,n',n'-tetramethyluroniumhexafluorophosphate
- FT-0642286
- 2-(1h-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumhexafluorophosphate
- 0-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
- O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluoro-phosphate
- J-505344
- O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluoro-phosphate
- 2-(1H-benzo[d][1,2,3]triazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate
- 0-benzotriazol-1-yl-N,N, N',N'-tetramethyluronium hexafluorophos-phate
- O-benzotriazol-1-yl-N,N,N',N'-tetramethyluroniumhexafluorophosphate
- benzotriazol-1-yl-n,n,n',n'-tetramethyluronium hexafluorophosphate
- SCHEMBL66487
- 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyl-uronium hexafluorophosphate
- BP-20106
- Methanaminium, N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, hexafluorophosphate(1-) (1:1)
- [benzotriazol-1-yloxy(dimethylamino) methylene]-dimethyl-ammonium hexafluorophosphate
- UQYZFNUUOSSNKT-UHFFFAOYSA-N
- N,N,N',N'-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate
- tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate
- 2-(1H-benzotriazole-1yl)-1,1,3,3-tetramethyluronium hexafluorophosphate
- O-(1-benzotriazolyl)-N,N,N', N'-tetramethyluronium hexafluorophosphate
- A936579
- [(benzotriazol-1-yloxy)-dimethylamino-methylene]dimethyl-ammonium hexafluoro phosphate
- 2-(1 H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate
- 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexaflurophosphate
- O-benzotriazol-1-yl -N,N,N',N'-tetramethyluronium hexafluorophosphate
- O-benzotriazole-N,N,N',N'-tetramethyl-uronium hexaflurophosphate
- N,N,N',N'-tetramethyl-O-(1H-benzotriazol-1-yl)-uronium hexafluoro-phosphate
- MDL： MFCD00075445
- Inchi： 1S/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1
- InChI Key： UQYZFNUUOSSNKT-UHFFFAOYSA-N
- SMILES： [P-](F)(F)(F)(F)(F)F.O(/C(/N(C)C)=[N+](\C)/C)N1C2C=CC=CC=2N=N1
- BRN： 7328329

Computed Properties

Exact Mass: 379.10000
Monoisotopic Mass: 379.09966612 g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 10
Heavy Atom Count: 24
Rotatable Bond Count: 3
Complexity: 350
Covalently-Bonded Unit Count: 2
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: nothing
Molecular Weight: 379.24
Topological Polar Surface Area: 46.2?2

Experimental Properties

Color/Form: White crystalline powder
Density: 1.5095
Melting Point: 200?°C (dec.) (lit.)
Boiling Point: No data available
Flash Point: 200℃
PH: 4.1 (1.6g/l, H2O)
Solubility: acetonitrile: 0.1?g/mL, clear
Stability/Shelf Life: Stable. Incompatible with oxidizing agents.
PSA: 59.78000
LogP: 3.43200
Decomposition: 200 oC
Solubility: Not determined
Sensitiveness: Easy to absorb moisture and sensitive to light
Vapor Pressure: No data available

HBTU Security Information

Symbol:
Prompt：warning
Signal Word：Warning
Hazard Statement： H315,H319,H335
Warning Statement： P261,P305+P351+P338
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Hazard Category Code： 36/37/38-42/43
Safety Instruction： S26-S36/37/39
FLUKA BRAND F CODES：8-10-21
Hazardous Material Identification：
Storage Condition：2-8°C
Risk Phrases：R20/21/22; R36/37/38

HBTU Customs Data

HS CODE：29339980

HBTU Pricemore >>

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SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H106174-100g	HBTU	94790-37-1	99%	100g	￥146.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H106174-25g	HBTU	94790-37-1	99%	25g	￥50.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H106174-500g	HBTU	94790-37-1	99%	500g	￥586.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H106174-5g	HBTU	94790-37-1	99%	5g	￥30.90	2023-09-02
YAN FENG KE JI （ BEI JING ） Co., Ltd.	H76692-25g	HBTU	94790-37-1	99%	25g	￥60	2023-09-19
YAN FENG KE JI （ BEI JING ） Co., Ltd.	H76692-100g	HBTU	94790-37-1	99%	100g	￥140	2023-09-19
YAN FENG KE JI （ BEI JING ） Co., Ltd.	H76692-500g	HBTU	94790-37-1	99%	500g	￥530	2023-09-19
Chemenu	CM326319-1000g	HBTU	94790-37-1	95%+	1000g	$200	2021-08-18
ChemScence	CS-W020191-500g	1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide（HBTU）	94790-37-1	99.83%	500g	$68.0	2022-04-26
ChemScence	CS-W020191-1000g	1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide	94790-37-1	99.83%	1000g	$155.0	2021-09-02

HBTU Production Method

HBTU Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:94790-37-1)HBTU

Order Number:LE2621008;LE5924

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:42

Price ($):discuss personally

Email:[email protected]

HBTU Spectrogram

1H NMR

300 MHz

DMSO

13C NMR

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Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
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J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552

Related Categories

Additional information on HBTU

Introduction to HBTU (CAS No. 94790-37-1) and Its Recent Applications in Chemical Biology

HBTU, chemically known as 1-Hydroxy-7-azabenzotriazole-1-tosylate, is a compound with the CAS number 94790-37-1. This reagent has garnered significant attention in the field of chemical biology due to its versatile applications in peptide synthesis and other biochemical processes. The compound is particularly valued for its role as an efficient coupling agent, facilitating the formation of amide bonds between carboxylic acids and amines under mild conditions. Its widespread use in pharmaceutical research and development underscores its importance in the synthesis of complex biomolecules.

The mechanism of action for HBTU revolves around its ability to activate carboxylic acids through the formation of a highly reactive intermediate. This intermediate, known as an activated ester, readily reacts with amines to form stable amide bonds. The presence of the hydroxy group and the tosylate moiety in HBTU enhances its reactivity and stability, making it an ideal choice for various synthetic applications. Recent studies have highlighted its efficacy in both solid-phase and solution-phase peptide synthesis, where it demonstrates superior yields and purity compared to traditional coupling agents.

In recent years, HBTU has been extensively studied for its applications in the synthesis of peptidomimetics, which are designed to mimic the biological activity of natural peptides but with improved stability and pharmacokinetic properties. For instance, researchers have utilized HBTU to synthesize peptidomimetics targeting enzyme inhibition, which has shown promise in treating various inflammatory and infectious diseases. The compound's ability to facilitate high-yielding peptide couplings has made it a cornerstone in the development of novel therapeutic agents.

Moreover, HBTU has found utility in the field of protein engineering, where it is employed to modify protein sequences for enhanced functionality or stability. The precision with which HBTU can couple amino acids allows researchers to tailor protein structures for specific biological applications. This has led to significant advancements in understanding protein-protein interactions and developing targeted therapies.

Recent breakthroughs in synthetic chemistry have further expanded the applications of HBTU. For example, researchers have developed novel methodologies using HBTU that enable the synthesis of cyclic peptides, which are known for their enhanced binding affinity and resistance to enzymatic degradation. These cyclic peptides have been explored as potential drug candidates for cancer therapy, showcasing the versatility of HBTU in addressing complex biological challenges.

The chemical stability of HBTU under various reaction conditions is another key factor contributing to its widespread use. Unlike some other coupling agents that require harsh conditions or stringent pH control, HBTU remains effective under a broad range of conditions, making it a convenient choice for synthetic chemists. This stability is attributed to its robust molecular structure, which resists degradation even in prolonged reactions or when exposed to mild oxidizing agents.

In conclusion, HBTU (CAS No. 94790-37-1) is a pivotal reagent in modern chemical biology, particularly in peptide synthesis and protein engineering. Its efficiency, stability, and versatility have made it an indispensable tool for researchers developing novel therapeutic agents. As our understanding of biological systems continues to evolve, the role of compounds like HBTU will undoubtedly expand, offering new opportunities for innovation and discovery.

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