Cas no 947687-02-7 (8-Ethyl Irinotecan)

8-Ethyl Irinotecan is a semi-synthetic derivative of the topoisomerase I inhibitor irinotecan, designed to enhance therapeutic efficacy and reduce adverse effects. This compound exhibits improved metabolic stability and pharmacokinetic properties compared to its parent molecule, making it a promising candidate for oncology applications. Its mechanism of action involves the inhibition of DNA topoisomerase I, leading to DNA damage and apoptosis in rapidly dividing cancer cells. The ethyl modification at the 8-position contributes to increased lipophilicity, potentially improving tissue penetration and bioavailability. Preclinical studies suggest it may offer a broader therapeutic window, with reduced gastrointestinal toxicity, while maintaining potent antitumor activity against colorectal and other solid tumors.
8-Ethyl Irinotecan structure
8-Ethyl Irinotecan structure
Product Name:8-Ethyl Irinotecan
CAS No:947687-02-7
MF:C35H42N4O6
MW:614.731189250946
CID:1059016
PubChem ID:58965010
Update Time:2025-05-26

8-Ethyl Irinotecan Chemical and Physical Properties

Names and Identifiers

    • 8-Ethyl Irinotecan
    • Irinotecan IMpurity G
    • [1,4 inverted exclamation mark-Bipiperidine]-1 inverted exclamation mark-carboxylic Acid (4S)-4,8,11-Triethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3 inverted exclamation mark,4 inverted exclamation mark :6,7]indolizino[1,2-b]quinolin-9-yl Ester
    • (4S)-4,8,11-Triethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl [1,4′-bipiperidine]-1′-carboxylate (ACI)
    • 8-Ethyl Irinotecan (Irinotecan Impurity)
    • OG7FYG3IZO
    • Irinotecan 8-Ethyl Impurity
    • 11-ETHYL IRINOTECAN [USP IMPURITY]
    • [(19S)-6,10,19-triethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate
    • (19S)-6,10,19-triethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0?,??.0?,?.0??,??]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl [1,4'-bipiperidine]-1'-carboxylate
    • DTXSID90730723
    • (1,4'-Bipiperidine)-1'-carboxylic acid, (4S)-4,8,11-triethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester
    • (S)-4,8,11-Triethyl-4-hydroxy-1H-pyrano(3,4:6,7)indolizino(1,2-b)quin oline-3,14(4H,12H)-dione-9-yl (1,4-bipiperidine)-1-carboxylate
    • SCHEMBL14422863
    • 8-EthylIrinotecan
    • UNII-OG7FYG3IZO
    • 947687-02-7
    • 11-Ethyl irinotecan
    • (4S)-4,8,11-Triethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
    • CS-0167468
    • (4S)-4,8,11-Triethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl (1,4'-bipiperidine)-1'-carboxylate
    • 11-Ethyl irinotecan [USP]
    • Inchi： 1S/C35H42N4O6/c1-4-21-16-28-24(17-30(21)45-34(42)38-14-10-22(11-15-38)37-12-8-7-9-13-37)23(5-2)25-19-39-29(31(25)36-28)18-27-26(32(39)40)20-44-33(41)35(27,43)6-3/h16-18,22,43H,4-15,19-20H2,1-3H3/t35-/m0/s1
    • InChI Key： IEKWXGPJFJGZSM-DHUJRADRSA-N
    • SMILES： O=C1C2COC([C@](C=2C=C2C3N=C4C=C(C(=CC4=C(CC)C=3CN12)OC(N1CCC(N2CCCCC2)CC1)=O)CC)(O)CC)=O

Computed Properties

  • Exact Mass: 614.31000
  • Monoisotopic Mass: 614.31043507g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 8
  • Heavy Atom Count: 45
  • Rotatable Bond Count: 6
  • Complexity: 1250
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.8
  • Topological Polar Surface Area: 113?2

Experimental Properties

  • PSA: 114.20000
  • LogP: 4.52930

8-Ethyl Irinotecan Security Information

8-Ethyl Irinotecan Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
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TRC
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TRC
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SHENG KE LU SI SHENG WU JI SHU
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 ￥101,534.00 2023-07-11
SHENG KE LU SI SHENG WU JI SHU
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8-Ethyl Irinotecan,
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 ￥101534.00 2023-09-05
A2B Chem LLC
AW53800-1mg
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 $421.00 2023-12-29
A2B Chem LLC
AW53800-5mg
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 $1103.00 2023-12-29
A2B Chem LLC
AW53800-25mg
8-Ethyl Irinotecan
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 $4106.00 2023-12-29
Ambeed
A312262-25mg
(S)-4,8,11-Triethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
 947687-02-7 95+%
25mg
 $4556.0 2025-04-14
MedChemExpress
HY-131174-1mg
8-Ethyl Irinotecan
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