• 1. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 2. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 3. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 4. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 5. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

Comprehensive Guide to 2-Chloro-5-Nitropyridine-4-Carbaldehyde (CAS No. 946136-72-7): Properties, Applications, and Market Insights

2-Chloro-5-nitropyridine-4-carbaldehyde (CAS No. 946136-72-7) is a specialized nitropyridine derivative with significant relevance in pharmaceutical and agrochemical research. This compound, characterized by its chloro and nitro functional groups, serves as a versatile intermediate in organic synthesis. Its unique molecular structure makes it valuable for constructing complex molecules, particularly in drug discovery and material science.

The growing demand for heterocyclic compounds like 2-chloro-5-nitropyridine-4-carbaldehyde is driven by advancements in medicinal chemistry. Researchers frequently search for "nitropyridine derivatives in drug development" or "applications of chloro-nitropyridine compounds," reflecting its importance in designing kinase inhibitors and antimicrobial agents. Its aldehyde group further enhances reactivity, enabling diverse chemical transformations.

From a synthetic perspective, 2-chloro-5-nitropyridine-4-carbaldehyde exhibits remarkable stability under standard conditions, making it suitable for multi-step reactions. Laboratories often inquire about "synthesis routes for nitropyridine aldehydes" or "handling precautions for halogenated nitropyridines," underscoring its technical significance. The compound's melting point (typically 120-125°C) and solubility profile (moderate in polar organic solvents) are frequently discussed in technical forums.

In material science applications, this nitropyridine building block contributes to the development of functionalized polymers and coordination complexes. Recent patent analyses reveal increasing interest in "nitropyridine-based ligands for catalysis" and "photoactive materials containing chloro-nitropyridine moieties." These applications align with the global trend toward specialized fine chemicals for advanced technologies.

The market for 2-chloro-5-nitropyridine-4-carbaldehyde shows steady growth, particularly in regions with strong pharmaceutical R&D infrastructure. Industry reports highlight queries like "suppliers of high-purity nitropyridine derivatives" and "custom synthesis of halogenated pyridine aldehydes." Regulatory-compliant manufacturing processes ensure consistent quality for research and industrial applications, with analytical methods including HPLC and NMR verification being standard practice.

Environmental and safety considerations for 946136-72-7 follow standard laboratory protocols for nitroaromatic compounds. While not classified as hazardous under normal handling conditions, proper ventilation and personal protective equipment are recommended. This aligns with industry searches for "safe handling of nitropyridine derivatives" and "storage conditions for reactive aldehydes."

Future research directions for 2-chloro-5-nitropyridine-4-carbaldehyde may explore its potential in bioconjugation chemistry and covalent inhibitor design, areas gaining traction in pharmaceutical innovation. The compound's dual functionality (electrophilic aldehyde and electron-deficient pyridine ring) positions it as valuable for developing targeted therapies, particularly in oncology and infectious disease research.

For researchers sourcing this material, key considerations include purity specifications (typically ≥98% by HPLC), packaging options (from gram to kilogram scale), and regulatory documentation availability. These factors address common search queries like "analytical data for 2-chloro-5-nitropyridine-4-carbaldehyde" and "bulk suppliers of CAS 946136-72-7," reflecting practical procurement needs in the scientific community.

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