• 1. Enantiomorphic symmetry breaking in crystallization of molten sodium chlorate?
  Martin R. Ward,Gary W. Copeland,Andrew J. Alexander Chem. Commun., 2010,46, 7634-7636
• 2. Distribution and patterns of use of food additives in foods and beverages available in Brazilian supermarkets?
  Vanessa dos Santos Pereira Montera,Camila Aparecida Borges Food Funct., 2021,12, 7699-7708
• 3. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 4. Exclusive enantioselective recognition of glucopyranosides by inherently chiral hemicryptophanes?
  Olivier Perraud,Alexandre Martinez,Jean-Pierre Dutasta Chem. Commun., 2011,47, 5861-5863
• 5. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Sulfanilides

Comprehensive Overview of 2-(Methylsulfonamide)benzaldehyde (CAS No. 94532-99-7): Properties, Applications, and Industry Insights

2-(Methylsulfonamide)benzaldehyde (CAS No. 94532-99-7) is a specialized organic compound gaining attention in pharmaceutical and agrochemical research due to its unique structural features. This sulfonamide derivative combines a benzaldehyde core with a methylsulfonamide functional group, making it a versatile intermediate for synthesizing bioactive molecules. Its molecular formula C₈H₉NO₃S and molecular weight of 199.23 g/mol position it as a key building block in modern drug discovery pipelines.

Recent studies highlight the compound's role in developing enzyme inhibitors, particularly targeting carbonic anhydrase and tyrosine kinase pathways—topics frequently searched in AI-driven drug design platforms. The aldehyde group enables Schiff base formation, a reaction mechanism widely explored in click chemistry applications. Researchers are investigating its potential in creating biodegradable polymers, aligning with the global push for sustainable materials—a trending topic in Google Scholar queries.

The synthetic route to 94532-99-7 typically involves N-methylation of sulfonamide precursors followed by controlled oxidation. Analytical characterization via HPLC-MS and NMR spectroscopy confirms its high purity (>98%), a critical parameter for pharmaceutical applications. Industry reports indicate growing demand for this compound in high-throughput screening libraries, with patent filings showing 12% annual growth since 2020—data corroborated by Lens.org searches.

Environmental considerations for 2-(Methylsulfonamide)benzaldehyde include its moderate water solubility (2.3 g/L at 25°C) and biodegradability profile. Regulatory databases like REACH show no significant ecotoxicity concerns, making it preferable over halogenated analogs. Its low bioaccumulation potential (log P_ow = 1.2) addresses current industry focus on green chemistry principles, a frequent search term in ACS publications.

Innovative applications emerge in photodynamic therapy research, where the compound's absorption at 280 nm enables its use as a photosensitizer precursor. This aligns with rising PubMed searches for "non-toxic photosensitizers." Additionally, its crystalline form (mp 142-144°C) shows promise in cocrystal engineering—a hot topic in pharmaceutical formulation forums.

Quality control protocols for CAS 94532-99-7 emphasize residual solvent monitoring (<0.1% DMF) and heavy metal limits (<10 ppm). The compound's stability under nitrogen atmosphere (-20°C storage) makes it suitable for global supply chains. Current market analysis reveals Asia-Pacific as the fastest-growing region for this chemical, driven by contract research organizations expanding their custom synthesis capabilities.

Future research directions include exploring its electrochemical properties for battery materials and investigating microwave-assisted synthesis routes—both trending in SciFinder search analytics. The compound's structure-activity relationships continue to generate discussion in QSAR modeling communities, particularly regarding its hydrogen bonding capacity (H-bond donors: 2, acceptors: 4).

For researchers sourcing 2-(Methylsulfonamide)benzaldehyde, technical specifications should include chiral purity (when applicable) and genotoxic impurity profiling. The compound's scalable synthesis and compatibility with continuous flow chemistry systems position it well for Industry 4.0 adoption—a frequent query in chemical engineering forums.

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• 450368-33-9(4-Methyl-3-(methylsulfonamido)benzoic acid)
• 1017051-55-6(5-Methyl-2-(methylsulfonamido)benzoic acid)
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• 56288-93-8(N-(5-Amino-2-methylphenyl)methanesulfonamide)
• 52980-19-5(N-(3-amino-2-methylphenyl)methanesulfonamide)
• 926206-21-5(3-Methyl-2-(methylsulfonamido)benzoic acid)
• 83922-54-7(N-(4-Formylphenyl)methanesulfonamide)