• 1. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 2. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
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• 5. Enantiomorphic symmetry breaking in crystallization of molten sodium chlorate?
  Martin R. Ward,Gary W. Copeland,Andrew J. Alexander Chem. Commun., 2010,46, 7634-7636

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

4-Bromo-2-(carboxymethyl)benzoic Acid: A Comprehensive Overview

4-Bromo-2-(carboxymethyl)benzoic acid, also known by its CAS number 943749-63-1, is a compound of significant interest in the fields of organic chemistry, pharmacology, and materials science. This compound is characterized by its unique structure, which combines a bromine atom at the para position and a carboxymethyl group at the meta position on the benzoic acid backbone. This arrangement imparts distinctive chemical properties, making it a valuable molecule for various applications.

The synthesis of 4-bromo-2-(carboxymethyl)benzoic acid typically involves multi-step organic reactions, including bromination, carboxylation, and oxidation processes. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly syntheses, reducing production costs and minimizing waste. These improvements have made the compound more accessible for large-scale applications in industries such as pharmaceuticals and agrochemicals.

In terms of chemical properties, 4-bromo-2-(carboxymethyl)benzoic acid exhibits high thermal stability and moderate solubility in polar solvents. Its bromine atom contributes to its reactivity in nucleophilic aromatic substitution reactions, while the carboxymethyl group enhances its ability to form hydrogen bonds, which is crucial for its role in biological systems.

Recent studies have highlighted the potential of 4-bromo-2-(carboxymethyl)benzoic acid as a building block in drug discovery. Researchers have explored its use in designing novel anti-inflammatory agents and anticancer drugs due to its ability to modulate key cellular pathways. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit potent inhibitory effects on COX-2 enzymes, suggesting their potential as nonsteroidal anti-inflammatory drugs (NSAIDs).

Beyond pharmacology, 4-bromo-2-(carboxymethyl)benzoic acid has found applications in materials science, particularly in the development of advanced polymers and coatings. Its ability to undergo polymerization under mild conditions has led to the creation of biodegradable materials with enhanced mechanical properties. These materials are being investigated for use in biomedical devices and sustainable packaging solutions.

The environmental impact of 4-bromo-2-(carboxymethyl)benzoic acid has also been a topic of recent research. Studies have shown that it undergoes rapid biodegradation under aerobic conditions, reducing its ecological footprint compared to traditional synthetic compounds. This attribute makes it an attractive option for eco-friendly chemical processes.

In conclusion, 4-bromo-2-(carboxymethyl)benzoic acid, with its unique structure and versatile properties, continues to be a focal point in both academic research and industrial applications. As advancements in synthetic methodologies and material science progress, this compound is poised to play an even more critical role in shaping future innovations across multiple disciplines.

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• 1403483-70-4(Methyl 4-bromo-2-(2-methoxy-2-oxoethyl)benzoate)
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