• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 3. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 4. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 5. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives

Comprehensive Overview of 2'-Fluoro-[1,1'-biphenyl]-3-sulfonyl chloride (CAS No. 942475-00-5)

2'-Fluoro-[1,1'-biphenyl]-3-sulfonyl chloride (CAS No. 942475-00-5) is a specialized sulfonyl chloride derivative widely utilized in pharmaceutical and agrochemical research. This compound, characterized by its fluorinated biphenyl core, serves as a critical intermediate in the synthesis of bioactive molecules. Its unique molecular structure enables selective reactivity, making it invaluable for cross-coupling reactions and sulfonamide formation. Researchers increasingly focus on its applications in drug discovery, particularly for targeting enzyme inhibition and receptor modulation.

The growing demand for fluorinated compounds in modern chemistry has elevated the importance of 2'-Fluoro-[1,1'-biphenyl]-3-sulfonyl chloride. With the rise of precision medicine and green chemistry, this compound aligns with trends favoring sustainable synthesis and low-toxicity intermediates. Its compatibility with microwave-assisted reactions and flow chemistry further enhances its appeal in high-throughput screening. Common queries such as "How to purify 2'-Fluoro-[1,1'-biphenyl]-3-sulfonyl chloride?" or "What solvents are compatible with this sulfonyl chloride?" reflect its technical relevance in labs.

From a structural-activity relationship perspective, the fluoro substituent at the 2'-position significantly influences electronic distribution, improving binding affinity in target molecules. This attribute is pivotal for designing kinase inhibitors and antiviral agents, areas dominating recent PubMed and SciFinder searches. Analytical techniques like HPLC and NMR are essential for quality control, addressing frequent questions like "How to validate the purity of CAS No. 942475-00-5?".

In industrial contexts, 942475-00-5 is often discussed alongside scale-up challenges and cost-effective synthesis. Innovations in catalytic fluorination have reduced production costs, while patent literature highlights its role in next-generation therapeutics. The compound's stability under anhydrous conditions and compatibility with Grignard reagents are frequently cited advantages in organic synthesis forums.

Environmental considerations also shape its applications. As regulations tighten around persistent organic pollutants, the biodegradability profile of 2'-Fluoro-[1,1'-biphenyl]-3-sulfonyl chloride derivatives gains attention. Researchers explore its potential in bioconjugation for diagnostic probes, tapping into the booming theranostics market. Searches for "Alternative to toxic sulfonyl chlorides" often lead to this compound due to its balanced reactivity and safety profile.

Looking ahead, CAS No. 942475-00-5 is poised to play a key role in fragment-based drug design (FBDD) and DNA-encoded library (DEL) platforms. Its structural versatility supports diverse scaffold hopping strategies, a hot topic in medicinal chemistry circles. With AI-driven retrosynthesis tools increasingly referencing this compound, its integration into automated discovery pipelines is expected to accelerate.

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