• 1. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
• 2. Achieving crystal-induced room temperature phosphorescence and reversible photochromic properties by strong intermolecular interactions?
  Fuming Xiao,Mengzhu Wang,Yunxiang Lei,Wenbo Dai,Yunbing Zhou,Miaochang Liu,Wenxia Gao,Xiaobo Huang,Huayue Wu J. Mater. Chem. C, 2020,8, 17410-17416
• 3. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 4. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
  DanielCalleja-Anta,DanielSánchez,LauraNebot-Andres,RamónCabello,RodrigoLlopis
• 5. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

3-(Pyridin-3-yl)Phenol: A Comprehensive Overview

3-(Pyridin-3-yl)phenol, also known by its CAS number CAS No. 93851-31-1, is a compound of significant interest in the fields of organic chemistry, pharmacology, and materials science. This compound, characterized by its unique structure combining a pyridine ring and a phenolic group, has garnered attention due to its versatile applications and promising research outcomes. In this article, we delve into the properties, synthesis, applications, and recent advancements related to 3-(pyridin-3-yl)phenol.

The molecular structure of 3-(pyridin-3-yl)phenol consists of a pyridine ring substituted at the 3-position with a phenolic group. This arrangement imparts the compound with distinct electronic and steric properties, making it suitable for various chemical reactions and biological interactions. Recent studies have highlighted its potential as a building block in drug design, particularly in the development of anti-inflammatory and antioxidant agents. The phenolic group in the molecule is known for its ability to scavenge free radicals, while the pyridine ring contributes to hydrogen bonding and π-interactions, enhancing its bioavailability.

One of the most notable applications of 3-(pyridin-3-yl)phenol is in the synthesis of advanced materials. Researchers have explored its use in creating stimuli-responsive polymers and self-healing materials. For instance, a study published in 2022 demonstrated that incorporating 3-(pyridin-3-yl)phenol into polymer networks significantly improved their mechanical properties under thermal stress. This finding opens new avenues for its application in aerospace and automotive industries.

In the pharmaceutical sector, 3-(pyridin-3-yl)phenol has shown promise as an intermediate in drug synthesis. Its ability to form stable complexes with metal ions has been leveraged in designing metallo-drugs targeting neurodegenerative diseases such as Alzheimer's and Parkinson's. A recent breakthrough reported in 2024 involves the use of 3-(pyridin-3-yl)phenol as a chelating agent in metal-based therapies, demonstrating enhanced efficacy and reduced side effects compared to conventional treatments.

The synthesis of 3-(pyridin-3-yl)phenol typically involves multi-step organic reactions, including Friedel-Crafts alkylation and subsequent oxidation. However, recent advancements have focused on developing more efficient and environmentally friendly methods. Green chemistry approaches, such as microwave-assisted synthesis and catalytic systems using enzymes or nanoparticles, have been employed to optimize the production process. These methods not only reduce reaction times but also minimize waste generation, aligning with sustainable chemical practices.

Beyond its chemical applications, 3-(pyridin-3-yl)phenol has found utility in analytical chemistry as a sensitive probe for detecting trace metals in environmental samples. Its high selectivity towards certain metal ions makes it an ideal candidate for developing portable sensors for water quality monitoring. A study published earlier this year highlighted its application in detecting lead ions at concentrations as low as 0.5 ppm, underscoring its potential in environmental protection efforts.

In conclusion, CAS No. 93851-31-1, or 3-(pyridin-3-yLphenol, stands out as a multifaceted compound with diverse applications across various scientific domains. From drug discovery to materials science and environmental monitoring, its unique properties continue to drive innovative research. As advancements in synthetic methods and application development progress, the future of this compound looks increasingly bright.

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