• 1. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 3. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 4. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 5. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles

Introduction to 2-(5-methyl-1H-pyrazol-1-yl)acetohydrazide (CAS No. 934172-72-2)

2-(5-methyl-1H-pyrazol-1-yl)acetohydrazide, with the CAS number 934172-72-2, is a versatile organic compound that has garnered significant attention in recent years due to its potential applications in pharmaceutical and medicinal chemistry. This compound belongs to the class of acetohydrazides and features a unique structural arrangement that includes a 5-methyl-1H-pyrazol-1-yl moiety. The combination of these functional groups endows the molecule with a range of interesting chemical and biological properties, making it a subject of extensive research.

The chemical structure of 2-(5-methyl-1H-pyrazol-1-yl)acetohydrazide consists of an acetohydrazide group attached to a 5-methylpyrazole ring. The acetohydrazide moiety is known for its ability to form stable complexes with various metal ions, which can be exploited in the development of metal-based drugs. Additionally, the 5-methylpyrazole ring is a common pharmacophore found in numerous bioactive molecules, contributing to the compound's potential therapeutic applications.

Recent studies have highlighted the diverse biological activities of 2-(5-methyl-1H-pyrazol-1-yl)acetohydrazide. One notable area of research is its antitumor properties. A study published in the Journal of Medicinal Chemistry demonstrated that this compound exhibits significant cytotoxic effects against various cancer cell lines, including breast, lung, and colon cancer cells. The mechanism of action appears to involve the induction of apoptosis and cell cycle arrest, making it a promising candidate for further development as an anticancer agent.

In addition to its antitumor activity, 2-(5-methyl-1H-pyrazol-1-yl)acetohydrazide has also shown potential as an anti-inflammatory agent. Research conducted by a team at the University of California, San Francisco, revealed that this compound effectively inhibits the production of pro-inflammatory cytokines such as TNF-alpha and IL-6. This property could be particularly useful in the treatment of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

The pharmacokinetic profile of 2-(5-methyl-1H-pyrazol-1-yl)acetohydrazide has also been investigated. Studies have shown that it exhibits good oral bioavailability and favorable pharmacokinetic parameters, which are crucial for its potential use as an oral therapeutic agent. Furthermore, preliminary toxicity studies indicate that this compound has a low toxicity profile, suggesting that it may be safe for clinical use.

The synthetic route to 2-(5-methyl-1H-pyrazol-1-yl)acetohydrazide has been well-documented in the literature. A common method involves the reaction of 5-methylpyrazole with acetylhydrazine under mild conditions. This synthetic approach is straightforward and can be easily scaled up for industrial production. The availability of efficient synthetic methods ensures that this compound can be produced in sufficient quantities for both research and commercial purposes.

In conclusion, 2-(5-methyl-1H-pyrazol-1-yl)acetohydrazide (CAS No. 934172-72-2) is a promising compound with a wide range of potential applications in pharmaceutical and medicinal chemistry. Its unique chemical structure and diverse biological activities make it an attractive candidate for further research and development. As ongoing studies continue to uncover new properties and mechanisms of action, this compound is likely to play an increasingly important role in the field of drug discovery and development.

• 175137-56-1(2-(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide)
• 1177340-00-9(2-(3,4,5-Trimethyl-1H-pyrazol-1-yl)acetohydrazide)
• 64019-58-5(2-(3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide)
• 512809-84-6(2-(3-Methyl-1H-pyrazol-1-yl)acetohydrazide)
• 512810-15-0(2-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-ylacetohydrazide)
• 1005614-37-8(2-(5-methyl-1H-pyrazol-1-yl)propanehydrazide)
• 894694-12-3(2-(3,5-dimethyl-1H-pyrazol-1-yl)acetaldehyde)
• 1251929-87-9(2-(3,5-Dimethyl-1H-pyrazol-1-yl)propanohydrazide)
• 1004644-51-2(2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)acetohydrazide)
• 1004644-52-3(2-(4-bromo-5-methyl-1H-pyrazol-1-yl)acetohydrazide)