• 1. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 2. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 4. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 5. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

Introduction to 4-Fluorobenzoic Acid-d4 (CAS No. 93111-25-2)

4-Fluorobenzoic Acid-d4, identified by the Chemical Abstracts Service (CAS) number 93111-25-2, is a deuterated derivative of 4-fluorobenzoic acid. This compound has garnered significant attention in the field of pharmaceutical and biochemical research due to its unique properties and applications. The introduction of deuterium atoms into the molecular structure enhances its stability and isotopic purity, making it an invaluable tool in analytical chemistry, drug metabolism studies, and mechanistic investigations.

The molecular formula of 4-Fluorobenzoic Acid-d4 is C?H?FDO?, where the deuterium (D) replaces one of the hydrogen atoms in the parent compound. This modification not only improves the compound's suitability for NMR spectroscopy but also allows researchers to study metabolic pathways with greater precision. The fluorine atom at the para position relative to the carboxylic acid group contributes to its reactivity and interaction with biological systems, making it a key intermediate in synthetic organic chemistry.

In recent years, advancements in mass spectrometry and chromatographic techniques have further highlighted the utility of 4-Fluorobenzoic Acid-d4. Its high isotopic purity ensures minimal interference in analytical assays, enabling researchers to achieve accurate and reliable results. This has been particularly beneficial in clinical pharmacology, where understanding drug metabolism is crucial for drug development and personalized medicine.

One of the most compelling applications of 4-Fluorobenzoic Acid-d4 is in the synthesis of fluorinated pharmaceuticals. Fluorinated compounds are known for their enhanced bioavailability, metabolic stability, and binding affinity to biological targets. The incorporation of deuterium into these molecules can lead to improved pharmacokinetic profiles, as demonstrated by recent studies on fluoroquinolone antibiotics and antiviral agents. The ability to track these modifications using 4-Fluorobenzoic Acid-d4 provides a powerful tool for medicinal chemists.

Recent research has also explored the role of fluorinated benzoic acids in materials science and polymer chemistry. The presence of a fluorine atom can influence the electronic properties and thermal stability of polymers, making them suitable for high-performance applications such as electronics and aerospace materials. The deuterated version, 4-Fluorobenzoic Acid-d4, offers a way to study these effects without compromising structural integrity or reactivity.

The synthesis of 4-Fluorobenzoic Acid-d4 typically involves fluorination followed by deuteration of benzoic acid derivatives. Advanced catalytic methods have been developed to achieve high yields and selectivity, ensuring that the final product meets stringent purity standards. These methods often leverage transition metal catalysts and optimized reaction conditions to minimize side products.

In conclusion, 4-Fluorobenzoic Acid-d4 (CAS No. 93111-25-2) represents a critical advancement in isotopic labeling for scientific research. Its applications span multiple disciplines, from pharmaceutical development to materials science, underscoring its versatility and importance. As research continues to evolve, the demand for high-purity deuterated compounds like 4-Fluorobenzoic Acid-d4 is expected to grow, driving further innovation in synthetic methodologies and analytical techniques.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)