• 1. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 2. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 3. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 4. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 5. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

3-Oxo-piperazine-2-carboxylic Acid (CAS No. 925890-01-3): A Comprehensive Overview

3-Oxo-piperazine-2-carboxylic Acid, identified by its CAS number 925890-01-3, is a significant compound in the field of pharmaceutical chemistry and biochemistry. This piperazine derivative has garnered considerable attention due to its versatile applications in drug development and synthetic chemistry. The compound's unique structural properties make it a valuable intermediate in the synthesis of various pharmacologically active molecules.

The molecular structure of 3-Oxo-piperazine-2-carboxylic Acid features a piperazine ring substituted with a carbonyl group at the 3-position and a carboxylic acid moiety at the 2-position. This configuration imparts distinct reactivity and binding characteristics, making it a preferred building block for medicinal chemists. The presence of both polar functional groups enhances its solubility in polar solvents, facilitating its use in various chemical reactions and biological assays.

In recent years, the pharmaceutical industry has seen a surge in the development of novel therapeutic agents targeting neurological and metabolic disorders. 3-Oxo-piperazine-2-carboxylic Acid has emerged as a key intermediate in the synthesis of potential drug candidates for these conditions. Its structural motif is closely related to several known bioactive compounds, suggesting its potential role in modulating biological pathways.

One of the most compelling applications of 3-Oxo-piperazine-2-carboxylic Acid is in the development of kinase inhibitors. Kinases are enzymes that play crucial roles in cell signaling pathways, and their dysregulation is associated with numerous diseases, including cancer and inflammatory disorders. Researchers have leveraged the compound's structural features to design molecules that selectively inhibit specific kinases, thereby offering new therapeutic strategies.

The synthesis of 3-Oxo-piperazine-2-carboxylic Acid typically involves multi-step organic reactions, starting from readily available precursors. Advanced synthetic methodologies, such as catalytic hydrogenation and palladium-catalyzed cross-coupling reactions, have been employed to achieve high yields and purity. These synthetic routes highlight the compound's importance as a synthetic intermediate in industrial-scale production.

Recent studies have also explored the pharmacological properties of derivatives of 3-Oxo-piperazine-2-carboxylic Acid. For instance, modifications at the piperazine ring have led to compounds with enhanced binding affinity to target proteins. Such derivatives are being evaluated in preclinical studies for their potential therapeutic efficacy. The findings from these studies underscore the compound's significance in drug discovery efforts.

The chemical stability of 3-Oxo-piperazine-2-carboxylic Acid under various conditions is another critical aspect that has been extensively studied. Understanding its stability profile is essential for optimizing storage conditions and ensuring its efficacy in pharmaceutical formulations. Researchers have employed spectroscopic techniques and thermal analysis methods to characterize its stability under different environmental conditions.

In conclusion, 3-Oxo-piperazine-2-carboxylic Acid (CAS No. 925890-01-3) represents a cornerstone compound in modern pharmaceutical chemistry. Its unique structural features and versatile reactivity make it indispensable in the synthesis of novel drug candidates. As research continues to uncover new applications and derivatives, this compound is poised to play an even more significant role in addressing unmet medical needs.

• 69777-15-7(2-Piperidinecarboxylicacid, hydrate (1:4))
• 777037-01-1(2-Piperidinecarboxylicacid, 6-(hydroxymethyl)-, (2R,6S)-)
• 161431-60-3(2-Piperidinecarboxylicacid, 6-(hydroxymethyl)-, cis- (9CI))
• 4347-18-6((2S)-4-oxopyrrolidine-2-carboxylic acid)
• 65060-18-6((2S)-4-oxopiperidine-2-carboxylic acid)
• 99571-58-1(6-Methylpiperidine-2-carboxylic acid)
• 3105-95-1((2S)-piperidine-2-carboxylic acid)
• 2002-02-0(4-Oxopyrrolidine-2-carboxylic acid)
• 287389-44-0(2-Piperidinecarboxylic-13Cacid (9CI))
• 789448-80-2(5-oxopiperidine-2-carboxylic acid)