• 1. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 2. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 3. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
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  Goonay Yousefalizadeh,Shideh Ahmadi,Nicholas J. Mosey,Kevin G. Stamplecoskie Nanoscale, 2021,13, 242-252

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinoline carboxylic acids

Research Brief on 6-Chloro-2-methylquinoline-3-carboxylic Acid (CAS: 92513-40-1): Recent Advances and Applications

6-Chloro-2-methylquinoline-3-carboxylic acid (CAS: 92513-40-1) is a quinoline derivative that has garnered significant attention in recent years due to its versatile applications in medicinal chemistry and drug discovery. This compound serves as a key intermediate in the synthesis of various biologically active molecules, particularly those targeting infectious diseases and inflammatory disorders. Recent studies have explored its potential as a scaffold for developing novel antimicrobial and anti-inflammatory agents, leveraging its unique chemical properties and structural features.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the efficacy of 6-chloro-2-methylquinoline-3-carboxylic acid derivatives as potent inhibitors of bacterial DNA gyrase, showcasing their potential as next-generation antibiotics. The researchers synthesized a series of analogs and evaluated their activity against drug-resistant strains of Staphylococcus aureus and Escherichia coli, with several compounds exhibiting MIC values in the low micromolar range. Molecular docking studies revealed that the chloro and carboxyl groups play critical roles in binding to the ATPase domain of the gyrase enzyme.

In the field of anti-inflammatory drug development, a recent patent application (WO2023051234) disclosed novel 6-chloro-2-methylquinoline-3-carboxylic acid derivatives that selectively inhibit COX-2 with minimal gastrointestinal side effects. The lead compound from this series showed 50-fold selectivity for COX-2 over COX-1 in in vitro assays, along with excellent pharmacokinetic properties in rodent models. This represents a significant improvement over traditional NSAIDs and could potentially address the cardiovascular risks associated with current COX-2 inhibitors.

The synthetic accessibility of 6-chloro-2-methylquinoline-3-carboxylic acid has also been improved through recent methodological advances. A 2024 publication in Organic Process Research & Development described a continuous-flow synthesis approach that increased yield from 68% to 92% while reducing reaction time from 12 hours to just 45 minutes. This green chemistry approach significantly reduces solvent waste and energy consumption, making the production process more sustainable and cost-effective for industrial-scale applications.

Emerging research has also explored the compound's potential in materials science. A study in ACS Applied Materials & Interfaces (2024) reported that metal-organic frameworks (MOFs) incorporating 6-chloro-2-methylquinoline-3-carboxylic acid as a linker exhibited exceptional stability and gas adsorption properties, particularly for CO2 capture applications. The unique electronic properties imparted by the quinoline core and carboxylic acid functionality make these materials promising for environmental remediation technologies.

Looking forward, the versatility of 6-chloro-2-methylquinoline-3-carboxylic acid continues to inspire innovation across multiple disciplines. Ongoing clinical trials are evaluating its derivatives as potential treatments for neglected tropical diseases, while computational studies are identifying new target proteins that may interact with this scaffold. The compound's balanced lipophilicity and hydrogen bonding capacity, combined with its synthetic tractability, position it as a valuable building block for future drug discovery efforts in both academic and industrial settings.

• 948290-22-0(7-Chloro-2,8-dimethylquinoline-3-carboxylic Acid)
• 948289-26-7(6-chloro-2,8-dimethyl-quinoline-3-carboxylic acid)
• 948289-44-9(6-chloro-8-methyl-quinoline-2,3-dicarboxylic acid)
• 948293-69-4(5,7-dichloro-2-methyl-quinoline-3-carboxylic acid)
• 920023-47-8(1H-Indole-3-carboxylic acid, 6-chloro-2-methyl-)
• 889942-69-2(5-chloro-2-methyl-1H-Indole-3-carboxylic acid)
• 948294-30-2( )
• 88344-65-4(2-Methylquinoline-3,4-dicarboxylic acid)
• 635-79-0(2-Methylquinoline-3-carboxylic acid)
• 948294-07-3(5-Chloro-2,8-dimethylquinoline-3-carboxylic Acid)