• 1. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 2. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 3. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 4. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 5. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles

Comprehensive Guide to 2-Bromo-4-fluoro-6-methylbenzonitrile (CAS No. 916792-09-1): Properties, Applications, and Industry Insights

2-Bromo-4-fluoro-6-methylbenzonitrile (CAS No. 916792-09-1) is a specialized halogenated benzonitrile derivative that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its bromine, fluorine, and methyl substituents, serves as a versatile building block in organic synthesis. Its unique molecular structure enables precise modifications, making it invaluable for developing high-performance materials and bioactive molecules.

In recent years, the demand for fluorinated aromatic compounds like 2-Bromo-4-fluoro-6-methylbenzonitrile has surged due to their enhanced metabolic stability and lipophilicity—properties critical in drug discovery. Researchers frequently search for "fluorinated nitriles in medicinal chemistry" or "brominated benzonitrile applications," reflecting its relevance in designing kinase inhibitors and antimicrobial agents. The compound’s electron-withdrawing groups also make it a candidate for organic electronics, aligning with trends in flexible electronics and OLED technologies.

Synthetically, CAS No. 916792-09-1 is prepared via palladium-catalyzed cross-coupling or nucleophilic aromatic substitution, methods often queried as "synthesis of bromo-fluoro benzonitriles." Its crystalline form and stability under ambient conditions are frequently discussed in forums focusing on scale-up challenges for fine chemicals. Analytical techniques like HPLC and NMR are essential for purity verification, a topic of interest for quality control professionals.

From an industrial perspective, 2-Bromo-4-fluoro-6-methylbenzonitrile aligns with the push toward sustainable halogenation methods. Searches for "green chemistry in halogenated intermediates" highlight the need for eco-friendly bromination protocols. Companies leveraging this compound often emphasize its role in high-value crop protection products, addressing global food security concerns—a hot topic in agrochemical innovation.

Regulatory compliance for 916792-09-1 remains straightforward, as it falls outside restricted categories. However, users frequently inquire about "handling halogenated nitriles safely," underscoring the importance of proper lab practices. The compound’s low acute toxicity profile, as per available SDS data, makes it a pragmatic choice for industrial applications.

In summary, 2-Bromo-4-fluoro-6-methylbenzonitrile exemplifies the intersection of structural precision and functional adaptability. Its utility spans drug development, materials science, and agrochemicals, resonating with current searches for "multifunctional aromatic nitriles" and "halogenated building blocks." As research advances, this compound is poised to play a pivotal role in next-generation scientific breakthroughs.

• 57381-39-2(2-Bromo-5-fluorobenzonitrile)
• 916792-11-5(2-Bromo-5-fluoro-4-methylbenzonitrile)
• 79544-27-7(2-Bromo-6-fluorobenzonitrile)
• 36282-26-5(2-Bromo-4-fluorobenzonitrile)
• 64695-82-5(2-Bromo-4,5-difluorobenzonitrile)
• 1255207-47-6(3-Bromo-6-fluoro-2-methylbenzonitrile)
• 1517611-20-9(2-Bromo-3,4-difluorobenzonitrile)
• 179898-34-1(3-Bromo-5-fluorobenzonitrile)
• 425379-16-4(2-Bromo-3-fluorobenzonitrile)
• 916792-07-9(2-Bromo-4-fluoro-5-methylbenzonitrile)